Overview
- Focuses specifically on PKC signaling at a mechanistic level in the context of cancer
- The first to present in a very detailed manner the implication of PKC isozymes in different types of cancers
- There will be a full section on anticancer agents that target PKC and on how PKC modulates the sensitivity of cancer cells to chemotherapeutic drugs
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Cancer Research (CUCR)
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Table of contents (23 chapters)
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Front Matter
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Regulation of PKC Isozyme Function: From Genes to Biochemistry
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Front Matter
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PKC Isozymes in the Control of Cell Function
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Front Matter
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PKC Isozymes in Cancer
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Front Matter
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Keywords
About this book
Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable.
This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).
Editors and Affiliations
Bibliographic Information
Book Title: Protein Kinase C in Cancer Signaling and Therapy
Editors: Marcelo G. Kazanietz
Series Title: Current Cancer Research
DOI: https://doi.org/10.1007/978-1-60761-543-9
Publisher: Humana Totowa, NJ
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Science+Business Media, LLC 2010
Hardcover ISBN: 978-1-60761-542-2Published: 17 June 2010
Softcover ISBN: 978-1-61779-691-3Published: 07 September 2012
eBook ISBN: 978-1-60761-543-9Published: 10 June 2010
Series ISSN: 2199-2584
Series E-ISSN: 2199-2592
Edition Number: 1
Number of Pages: XIV, 494
Number of Illustrations: 26 b/w illustrations, 11 illustrations in colour
Topics: Cancer Research, Pharmacology/Toxicology