Editors:
- For the physician-scientist treating patients
- Describes advantages and pitfalls of experimental models currently in use
- Leading edge techniques
- Includes supplementary material: sn.pub/extras
Part of the book series: Molecular and Translational Medicine (MOLEMED)
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Table of contents (10 chapters)
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Front Matter
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Back Matter
About this book
This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included.
Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.
Reviews
From the reviews:
“This is an important resource, providing a mechanistic understanding of the signaling event in cancer for developing effective targeted cancer therapies, as well as computational biology and systems theory. … great value to oncologists and physician-scientists treating patients, and translational scientists … . even students interested in this field will find it useful. … an important book for understanding major mechanisms of resistance to targeted cancer therapeutic agents as well as microRNA as a potential therapy capable of targeting multiple cancer signaling pathways.” (Omer Iqbal, Doody’s Review Service, September, 2011)
“The book provides a well-balanced insight into the topic of drug resistance … . the reader can find a lot of information about the progress and inspiration how to overcome the cancer resistance. The book represents a useful source of knowledge for cell and molecular biologists, geneticists, professionals in bioinformatics, researchers and physicians working in translational oncology.” (J. Sedlak, Neoplasma, Issue 6, November-December, 2012)
Editors and Affiliations
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Health System, Deptartment of Microbiology and Cancer C, University of Virginia, Charlottesville, USA
Daniel Gioeli
Bibliographic Information
Book Title: Targeted Therapies
Book Subtitle: Mechanisms of Resistance
Editors: Daniel Gioeli
Series Title: Molecular and Translational Medicine
DOI: https://doi.org/10.1007/978-1-60761-478-4
Publisher: Humana Totowa, NJ
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Science+Business Media, LLC 2011
Hardcover ISBN: 978-1-60761-477-7Published: 29 June 2011
Softcover ISBN: 978-1-61779-744-6Published: 14 July 2013
eBook ISBN: 978-1-60761-478-4Published: 02 June 2011
Series ISSN: 2197-7852
Series E-ISSN: 2197-7860
Edition Number: 1
Number of Pages: XIV, 202
Topics: Oncology, Molecular Medicine, Cancer Research