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  • © 2012

Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma

  • Reviews major advances in molecular methods, using an evidence-based perspective
  • Explores powerful tools for determining treatment decisions
  • An essential resource for oncologists, dermatologists, pathologists, and melanoma researchers
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Clinical Pathology (CCPATH)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xiv
  2. Diagnostic and Prognostic Biomarkers in Melanoma: Current State of Play

    • Jochen Utikal, Jürgen C. Becker, Selma Ugurel
    Pages 9-18
  3. Molecular Pathogenesis of Melanoma: Established and Novel Pathways

    • Paolo Antonio Ascierto, Maria Libera Ascierto, Mariaelena Capone, Zendee Elaba, Michael J. Murphy, Giuseppe Palmieri
    Pages 19-37
  4. Staging of Melanoma

    • Zendee Elaba, Michael J. Murphy, Philip Kerr, Jane M. Grant-Kels
    Pages 39-48
  5. Clinical and Histopathological Parameters in Melanoma

    • Cheryl Bilinski, Avery LaChance, Michael J. Murphy
    Pages 49-67
  6. mRNA Biomarkers in Melanoma

    • Giovanna Chiorino, Maria Scatolini
    Pages 79-88
  7. Epigenetic Biomarkers in Melanoma

    • Suhu Liu, Suping Ren, Paul M. Howell Jr., Adam I. Riker
    Pages 89-112
  8. MicroRNA Biomarkers in Melanoma

    • Jim Kozubek, Faseeha Altaf, Soheil Sam Dadras
    Pages 113-126
  9. MicroRNAs as Biomarkers and Therapeutic Targets in Melanoma

    • Daniel W. Mueller, Anja K. Bosserhoff
    Pages 127-144
  10. Mitochondrial DNA Biomarkers in Melanoma

    • Mark L. Steinberg
    Pages 145-157
  11. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (A) Diagnosis

    • Steven J. Ohsie, Basil A. Horst, Alistair Cochran, Scott W. Binder
    Pages 159-176
  12. Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (B) Prognostication

    • Basil A. Horst, Steven J. Ohsie, Alistair Cochran, Scott W. Binder
    Pages 177-188
  13. Tissue-Based Protein Biomarkers in Melanoma: Mass Spectrometry-Based Strategies

    • Michael J. Murphy, Karim Rezaul, David K. Han
    Pages 189-194
  14. Serological Biomarkers in Melanoma

    • Mel Ziman, Michael Millward, Robert Pearce, Mark Lee
    Pages 195-208
  15. Molecular Markers of Lymph Node Disease in Melanoma

    • Sandro Pasquali, Augustinus P. T. van der Ploeg, Simone Mocellin
    Pages 209-226
  16. Melanoma Cell Propagation: Cancer Stem Cell, Clonal Evolution and Interconversion Models of Tumorigenicity

    • Qiuzhen Liu, Marianna Sabatino, David F. Stroncek, Ping Jin, Francesco M. Marincola, Ena Wang
    Pages 227-241
  17. Chemotherapy for Melanoma

    • Hedwig Stanisz, Thomas Vogt, Knuth Rass
    Pages 247-263

About this book

This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.

Reviews

From the reviews:

“This is a comprehensive overview of biomarkers as they relate to pathogenesis and clinical utility in the diagnosis, staging, and treatment of melanoma. … The audience is practitioners specializing in melanoma, including dermatologists, surgeons, and oncologists, as well as researchers in the field. … book broadly explores the role of molecular diagnostic techniques and specific biomarkers which may serve to facilitate more accurate diagnoses and identify early-stage melanoma patients with high risk for metastasis. … I highly recommend this book for melanoma clinicians and researchers.” (Susan M. Swetter, Doody’s Book Reviews, July, 2012)

Editors and Affiliations

  • Health Center, Department of Dermatology, University of Connecticut, Farmington, USA

    Michael J. Murphy

Bibliographic Information

  • Book Title: Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma

  • Editors: Michael J. Murphy

  • Series Title: Current Clinical Pathology

  • DOI: https://doi.org/10.1007/978-1-60761-433-3

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-60761-432-6Published: 01 December 2011

  • Softcover ISBN: 978-1-4939-6186-3Published: 23 August 2016

  • eBook ISBN: 978-1-60761-433-3Published: 02 December 2011

  • Series ISSN: 2197-781X

  • Series E-ISSN: 2197-7828

  • Edition Number: 1

  • Number of Pages: XIV, 322

  • Topics: Pathology, Oncology, Dermatology

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 249.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access