Amyloid and Related Disorders

Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits.

Amyloid and Related Disorders presents an overview of the most

recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.

• Abnormal protein deposition diseases
• Amyloidoses
• Cryoglobulinemia
• Plasma cell dyscrasia
• Renal pathology

From the reviews:

“This book is an outstandingly detailed review of the pathology of amyloid diseases … . this book is a ‘must read’ and should be kept as a handy reference for amyloidosis centers, for pathologists and for all clinicians with an interest in amyloid diseases. The breadth of pathology is extensive, the histology presented is beyond compare and the thorough referencing is superb. The editors are to be congratulated for an outstanding resource for the pathology of amyloidosis and related disorders.” (Martha Skinner, Amyloid, July, 2013)

“This comprehensive book is the first to integrate the clinical and pathological aspects of the diagnosis and treatment of amyloid and related disorders. … It is written primarily for pathologists, but it also includes relevant information for clinical practitioners interested in the early diagnosis of amyloidoses. … Overall this is a comprehensive, well-written, and clinically pertinent reference on amyloidosis and related disorders. … The color images supplement well the detailed text, making it an excellent resource for pathologists as well as clinicians.” (Melissa S. Jacobs, Doody’s Review Service, August, 2012)

• Bldg#110, Rm#2242, Department of Pathology, Loyola University Medical Center, Maywood, USA

  Maria M. Picken MD, PhD, FASN

• , Department of Laboratory Medicine and Pa, Mayo Clinic, Rochester, USA

  Ahmet Dogan, M.D., Ph.D.

• , Department of Renal Pathology, Bostwick Laboratories, Orlando, USA

  Guillermo A. Herrera, M.D.

Policies and ethics