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Visual Dysfunction in Diabetes

The Science of Patient Impairment and Health Care

  • Details the role of neuronal, glial, and inflammatory components in early stages of diabetic retinopathy
  • Proposes new perspective on diabetic retinopathy, maintaining it is the result of an interacting spectrum of changes affecting many different cell types
  • Presents a new approach to following diabetic retinopathy through its various stages of progression
  • Covers recent genetics and molecular mechanisms identified with the progression of the disease
  • Explores the risk factors and complications and innovative screening methods, such as the use of ERGs, to diagnose the earliest stages of diabetic retinopathy
  • Includes supplementary material: sn.pub/extras

Part of the book series: Ophthalmology Research (OPHRES)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xv
  2. Living with Diabetic Retinopathy

    1. Front Matter

      Pages 1-1
  3. Living with Diabetic Retinopathy

  4. How Is Diabetic Retinopathy Detected?

    1. Front Matter

      Pages 15-15
  5. How does diabetes affect the Eye?

    1. Front Matter

      Pages 43-43
    2. Corneal Diabetic Neuropathy

      • Edoardo Midena
      Pages 45-51
    3. Clinical Phenotypes of Diabetic Retinopathy

      • José Cunha-Vaz, Rui Bernardes, Conceição Lobo
      Pages 53-68
    4. Visual Psychophysics in Diabetic Retinopathy

      • Edoardo Midena, Stela Vujosevic
      Pages 69-103
    5. Molecular Regulation of Endothelial Cell Tight Junctions and the Blood-Retinal Barrier

      • E. Aaron Runkle, Paul M. Titchenell, David A. Antonetti
      Pages 123-141
    6. Capillary Degeneration in Diabetic Retinopathy

      • Timothy S. Kern
      Pages 143-155
    7. Proteases in Diabetic Retinopathy

      • Sampathkumar Rangasamy, Paul McGuire, Arup Das
      Pages 157-172
    8. Neurodegeneration in Diabetic Retinopathy

      • Alistair J. Barber, William F. Robinson, Gregory R. Jackson
      Pages 189-209
    9. Glucose-Induced Cellular Signaling in Diabetic Retinopathy

      • Zia A. Khan, Subrata Chakrabarti
      Pages 211-232
    10. IGFBP-3 as a Regulator of the Growth-Hormone/Insulin-Like Growth Factor Pathway in Proliferative Retinopathies

      • Andreas Stahl, Ann Hellstrom, Chatarina Lofqvist, Lois Smith
      Pages 233-244
    11. Neurotrophic Factors in Diabetic Retinopathy

      • Anne R. Murray, Jian-xing Ma
      Pages 245-259
    12. The Role of CTGF in Diabetic Retinopathy

      • R. J. van Geest, E. J. Kuiper, I. Klaassen, C. J. F. van Noorden, R. O. Schlingemann
      Pages 261-285

About this book

An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye.  With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied.  Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment?  Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations?  The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutic

s will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.

Reviews

“It succeeds in summarizing recent advancements in our knowledge in the field with a well illustrated presentation, up-to-date references, and an authorship selected from an international group of respected investigators with proven contributions to the field. … It could be recommended as a reference for anyone interested in the basic mechanisms of the disease, its ocular manifestations, and treatment options.” (Radouil Tzekov, Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 253 (6), June, 2015)

Editors and Affiliations

  • Milton S. Hershey Medical Center, Dept. Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, USA

    Joyce Tombran-Tink, Colin J. Barnstable

  • Molecular and Integrative Physiology, Ophthalmology and Visual Sciences, Kellogg Eye Center, Ann Arbor, USA

    Thomas W. Gardner

Bibliographic Information

  • Book Title: Visual Dysfunction in Diabetes

  • Book Subtitle: The Science of Patient Impairment and Health Care

  • Editors: Joyce Tombran-Tink, Colin J. Barnstable, Thomas W. Gardner

  • Series Title: Ophthalmology Research

  • DOI: https://doi.org/10.1007/978-1-60761-150-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-60761-149-3Published: 15 December 2011

  • Softcover ISBN: 978-1-4939-6168-9Published: 23 August 2016

  • eBook ISBN: 978-1-60761-150-9Published: 16 December 2011

  • Edition Number: 1

  • Number of Pages: XV, 379

  • Topics: Ophthalmology, Endocrinology, Neurosciences

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access