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Telomeres and Telomerase in Cancer

  • Book
  • © 2009

Overview

Editors:
  1. Keiko Hiyama

    1. Dept. Translational Cancer Research, Hiroshima University, Hiroshima, Japan

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  • This book will focus on telomere and telomerase in human cancers and may provide medical doctors, pathologists, and translational cancer researchers with a deep understanding of these unique and fascinating molecules, as well as hot topics in clinical applications

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Basic Background

    1. Telomeres and Telomerase in Humans

      • Keiko Hiyama, Eiso Hiyama, Jerry W. Shay
      Pages 3-21

    2. Telomere-Binding Proteins in Humans

      • Nadya Dimitrova
      Pages 23-46

    3. Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms

      • Amy N. Depcrynski, Patrick C. Sachs, Lynne W. Elmore, Shawn E. Holt
      Pages 47-85

    4. Telomere Dysfunction and the DNA Damage Response

      • Malissa C. Diehl, Lynne W. Elmore, Shawn E. Holt
      Pages 87-125

    5. Alternative Lengthening of Telomeres in Human Cells

      • Hilda A. Pickett, Roger R. Reddel
      Pages 127-148

    6. Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer

      • Xin Huang, Zhenyu Ju
      Pages 149-167

  3. Telomeres and Telomerase in Human Cancers

    1. Role of Telomeres and Telomerase in Cancer

      • Keiko Hiyama, Eiso Hiyama, Keiji Tanimoto, Masahiko Nishiyama
      Pages 171-180

    2. Diagnostic Value I: Solid Tumors

      • Eiso Hiyama, Keiko Hiyama
      Pages 181-210

    3. Diagnostic Value II: Hematopoietic Malignancies

      • H. Ohyashiki Junko, Ohyashiki Kazuma
      Pages 211-224

    4. Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors

      • Brittney-Shea Herbert, Erin M. Goldblatt
      Pages 225-249

    5. Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors

      • Chandanamali Punchihewa, Danzhou Yang
      Pages 251-280

    6. Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors

      • Hiroyuki Seimiya, Takashi Tsuruo
      Pages 281-291

    7. Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer

      • Toshiyoshi Fujiwara, Yasuo Urata, Noriaki Tanaka
      Pages 293-312

  4. Experimental Protocols

    1. Protocol I: Telomerase Activity and Telomerase Expression

      • Eiso Hiyama
      Pages 315-335

    2. Protocol II: Importance and Methods of Telomere G-Tail Length Quantification

      • Akira Shimamoto, Eriko Aoki, Angie M. Sera, Hidetoshi Tahara
      Pages 337-350

    3. Protocol III: Detection of Alternative Lengthening of Telomeres

      • Wei-Qin Jiang, Jeremy D. Henson, A. Neumann Axel, R. Reddel Roger
      Pages 351-364

  5. Back Matter

    Pages 365-373
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Keywords

About this book

Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

Editors and Affiliations

  • Dept. Translational Cancer Research, Hiroshima University, Hiroshima, Japan

    Keiko Hiyama

Bibliographic Information

  • Book Title: Telomeres and Telomerase in Cancer

  • Editors: Keiko Hiyama

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-60327-879-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2009

  • Hardcover ISBN: 978-1-60327-306-0Published: 27 February 2009

  • Softcover ISBN: 978-1-61737-888-1Published: 19 November 2010

  • eBook ISBN: 978-1-60327-879-9Published: 18 March 2009

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XII, 380

  • Number of Illustrations: 41 b/w illustrations, 19 illustrations in colour

  • Topics: Cancer Research, Oncology, Pharmacology/Toxicology

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