Antithrombotic Drug Therapy in Cardiovascular Disease

1. Front Matter

   Pages i-xi

   PDF

2. Basic Principles

   1. Front Matter

      Pages 1-1

      PDF

   2. Platelets in Arterial Thrombosis

      • Edward F. Plow, Peter Kelly

      Pages 3-17

   3. The Role of Coagulation in Arterial and Venous Thrombosis

      • Kandice Kottke-Marchant

      Pages 19-38

   4. The Link Between Inflammation and Thrombosis

      • John H. Cleator, Mark Robbins

      Pages 39-61

   5. The Genetics of Thrombosis

      • Svati H. Shah, Richard C. Becker

      Pages 63-114

3. Antithrombotic Therapy for Stable Coronary Atherosclerotic Disease

   1. Front Matter

      Pages 116-116

      PDF

   2. Aspirin in Primary and Secondary Prevention of Cardiovascular Disease

      • Jinesh Kochar, J. Michael Gaziano

      Pages 117-129

   3. Thienopyridines in Stable Coronary Disease

      • Marcus D. Flather, Dipak Kotecha

      Pages 131-141

4. Antithrombotic Therapy for NSTE ACS

   1. Front Matter

      Pages 144-144

      PDF

   2. Antiplatelet Therapies in Unstable Angina and Non-ST Segment Elevation Myocardial Infarction

      • Saif Anwaruddin, Deepak L. Bhatt

      Pages 145-163

   3. Unfractionated Heparin and Enoxaparin for the Management of Non-ST-Segment Elevation Acute Coronary Syndromes

      • Pierluigi Tricoci, Kenneth W. Mahaffey

      Pages 165-181

   4. Direct Thrombin Inhibitors in Acute Coronary Syndromes

      • Tyler L. Taigen, James E. Harvey, A. Michael Lincoff

      Pages 183-201

   5. Synthetic Factor Xa Inhibition in Acute Coronary Syndromes

      • Michael S. Kim, Robert L. Page, Ivan P. Casserly

      Pages 203-215

5. Antithrombotic Therapy for STEMI

   1. Front Matter

      Pages 219-219

      PDF

   2. Antiplatelet Therapies: Aspirin, Clopidogrel and Thienopyridines, and Glycoprotein IIb/IIIa Inhibitors for the Management of ST-Segment Elevation Myocardial Infarction

      • Rory B. Weiner, Marc S. Sabatine

      Pages 219-233

   3. Antithrombin Therapy for Acute ST-Segment Elevation Myocardial Infarction

      • John M. Galla, Arman T. Askari

      Pages 235-246

   4. Fibrinolysis and Facilitated PCI

      • Ryan D. Christofferson, Sorin J. Brener

      Pages 247-257

6. Antithrombotic Therapy in Interventional Cardiology

   1. Front Matter

      Pages 260-260

      PDF

   2. Antithrombotic Therapy in Percutaneous Coronary Intervention

      • Adrian W. Messerli

      Pages 261-282

Substantial morbidity and mortality remains associated with thrombotic events has stimulated the rapid expansion of the available armamentarium to combat pathologic thrombosis. Pathologic thrombosis plays an essential role in the pathogenesis of acute coronary syndromes (ACS), ischemic complications of percutaneous coronary intervention (PCI), venous thromboembolic disease, and embolic complications of arrhythmias and various cardiomyopathies.

Written by experts in the field, Antithrombotic Drug Therapy in Cardiovascular Disease carefully examines individual and various combinations of the available antithrombotic regimens including fibrinolytic agents, antiplatelet therapies (aspirin, thieneopyridines, glycoprotein IIb/IIIa inhibitors), and anticoagulant therapies (unfractionated heparin, low-molecular-weight heparins, direct thrombin inhibitors, and synthetic factor X inhibitors), non-ST-segment elevation (NSTE) ACS and ST-segment elevation myocardial infarction (STEMI). A detailed overview, Antithrombotic Drug Therapy in Cardiovascular Disease presents the evidence demonstrating the efficacy of available antithrombotic therapies in specific disease states such as atrial fibrillation, cardiomyopathy, valvular heart disease, and heparin-induced thrombocytopenia (HIT).

• Antiplatelet therapies
• Antithrombotic therapies
• Atrial fibrillation
• Deep vein thrombosis
• Myocardial infarction
• Pulmonary embolism
• Thrombosis
• Unstable angina
• cardiovascular

From the reviews: Despite substantial therapeutic progress, considerable morbidity and mortality remains associated with thrombotic events but rapid expansion of the available armamentarium to combat pathologic thrombosis is nicely summarized in this excellent new book which becomes a valuable guide to improved therapy. The experts from the field, selected by its editors, survey individual and various combinations of the available antithrombotic regimens including fibrinolytic agents, antiplatelet therapies (aspirin, thieneopyridines, glycoprotein IIb/IIIa inhibitors), and anticogulant therapies (unfractionated heparin, low-molecular-weight heparins, direct thrombin inhibitors, and synthetic factor X inhibitors). The treatments discussed are up-to-date methods for management of common cardiovascular thrombotic problems designed for appropriate clinical use. Numerous illustrations, tables and figures throughout the book become particularly helpful for the reader. There are seven major divisions covered by twenty four chapters; most of which are multi-authored and include: Basic Principles, Antithrombotic Therapy for Stable Coronary Atherosclerotic Disease, Antithrombotic Therapy for NSTE ACS, Antithrombotic Therapy for STEMI. Antithrombotic Therapy in Interventional Cardiology, Antithrombotic Therapy in Venous Thromboembolism, and Clinical Considerations. The coagulationist should find this text to be a valuable addition to his/her office reference book shelf. William H Wehrmacher MD FACP FACC Harry L Messmore MD FACP from Comprehensive Therapy - 2010 “The chapter authors of this multiauthored book on antithrombotic drug therapy in cardiovascular disease are national and international thought leaders in their respective fields. … The intended audience includes medical students, allied health professionals, physicians in training, and cardiovascular physicians. … This will be a valuable resource for healthcare providers in the field of cardiovasculardisease management. The authors have met their objective of providing a high quality, evidence-based review of this field.” (Timir Paul, Doody’s Review Service, March, 2009)

• Western Reserve Heart Care, Hudson, U.S.A.

  Arman T. Askari

• Dept. Cardiovascular Medicine, Cleveland Clinic, Cleveland, U.S.A.

  A. Michael Lincoff

Policies and ethics