BLyS Ligands and Receptors

1. Front Matter

   Pages i-xiii

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2. The Beautiful Structures of BAFF, APRIL, and Their Receptors

   • Pascal Schneider

   Pages 1-18

3. BAFF Receptor Regulation of Peripheral B-Lymphocyte Survival and Development

   • Wasif N. Khan, Nicholas P. Shinners, Iris Castro, Kristen L. Hoek

   Pages 19-41

4. Regulation of B-Cell Self-Tolerance By BAFF and the Molecular Basis of Its Action

   • Sandra Gardam, Robert Brink

   Pages 43-63

5. Role of BAFF and APRIL in Antibody Production and Diversification

   • Andrea Cerutti, Kang Chen

   Pages 65-92

6. Signal Transduction by Receptors for BAFF and APRIL

   • Joanne M. Hildebrand, Ping Xie, Gail A. Bishop

   Pages 93-114

7. TACI Signaling and Its Role in Immunity

   • Richard J. Bram

   Pages 115-124

8. The BAFF/APRIL System in Autoimmunity

   • Fabienne Mackay, William A. Figgett, Pali Verma, Xavier Mariette

   Pages 125-160

9. Systemic Immune-Based Rheumatic Diseases: Blissless States of BLySfulness

   • William Stohl

   Pages 161-193

10. The Role of BAFF and APRIL in Regulating Human B-Cell Behaviour: Implications for Disease Pathogenesis

    • Stuart G. Tangye, David A Fulcher

    Pages 195-220

11. Translation of BAFF Inhibition from Mouse to Non-human Primate and Human

    • Lachy McLean, Dhaya Seshasayee, Susan L. Kalled, Flavius Martin

    Pages 221-243

12. BLyS/BR3 Receptor Signaling in the Biology and Pathophysiology of Aggressive B-Cell Lymphomas

    • Lingchen Fu, Lan V. Pham, Yen-chiu Lin-Lee, Archito T. Tamayo, Richard J. Ford

    Pages 245-263

13. Tipping the Scales of Survival: The Role of BLyS in B-Cell Malignancies

    • Anne J. Novak, Stephen M. Ansell

    Pages 265-282

14. Back Matter

    Pages 283-289

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Discovery of the BLyS (also known as BAFF) family of ligands and receptors has yielded a paradigm shift in our view of B-lymphocyte selection, survival, activation, and homeostasis. Previously, the B-cell antigen receptor (BCR) was viewed as the sole mediator of these parameters, in which BCR signals were not only dominant but were also linearly related to consequent outcomes. However, appreciating that BLyS signaling is an equal partner in establishing and maintaining B-cell pools in- cated that additional regulatory complexity – apparently based on population density and homeostatic demands – had to be included in models of B-cell behavior. This mounting interest was ampli?ed by evidence of a clear relationship to autoim- nity. The resulting ?urry of research activity has yielded a wealth of information and insights, impacting basic concepts in B-cell tolerance and activation as well as revealing novel translational strategies for autoimmunity, neoplasia, and transplant tolerance. This book includes 12 chapters that together yield an overview of these advances and ideas. The initial excitement generated by associations with humoral autoimmunity, coupled with profound B lineage phenotypes in knockout mouse models, prompted immediate questions: What do these receptors and cytokines look like, how do they interact, what cells express them, and how does this inform our understating of their biology? Indeed, probing the structural features of BLyS family ligands and rec- tors has afforded substantial insight, as have studies directed toward understanding the basic biological actions of these molecules.

• Antigen
• autoimmunity
• diseases
• pathogenesis
• pathophysiology
• physiology

• School of Medicine, University of Pennsylvania, Philadelphia, U.S.A.

  Michael P. Cancro

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