Overview
- Editors:
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Voon L. Chan
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Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada
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Philip M. Sherman
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Department of Paediatrics Department of Laboratory Medicine and Pathobiology Hospital for Sick Children, University of Toronto, Toronto, Canada
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Billy Bourke
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Children’s Research Center, Our Lady’s Hospital for Sick Children, School of Medicine and Medical Science, Dublin, Ireland
Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, Ireland
- Fundamental information on bacterial genomes and comprehensive analysis of bacterial pathogens
- Summarizes the current understanding of the structure and organization of the genetic blue-print of bacteria
- Major findings about bacterial genomes and their impact on strategy and approach for investigating mechanisms of pathogenesis of infectious diseases
- Focus on value and power of genomics, proteomics, glycomics, and bioinformatics as applied to selected specific bacterial pathogens
- Includes supplementary material: sn.pub/extras
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Table of contents (14 chapters)
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Front Matter
Pages i-xiii
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- Voon Loong Chan, Philip M. Sherman, Billy Bourke
Pages 21-30
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- Voon Loong Chan, Philip M. Sherman, Billy Bourke
Pages 31-39
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- Huey-Lan Huang, Wen-Chen Yeh
Pages 41-61
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- John Kelly, Jean-Robert Brisson, N. Martin Young, Harold C. Jarrell, Christine M. Szymanski
Pages 63-90
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- Zhongming Ge, David B. Schauer
Pages 91-107
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- Dieter M. Bulach, Torsten Seemann, Richard L. Zuerner, Ben Adler
Pages 109-123
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- David C. Alexander, Jun Liu
Pages 151-174
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- James B. Bliska, Michelle B. Ryndak, Jens P. Grabenstein
Pages 213-226
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- William S. Jermyn, Yvonne A. O’Shea, Anne Marie Quirke, E. Fidelma Boyd
Pages 227-254
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- Philip M. Sherman, Billy Bourke, Voon Loong Chan
Pages 255-264
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Back Matter
Pages 265-270
About this book
The first bacterial genome, Haemophilus influenzae, was completely sequenced, annotated, and published in 1995. Today, more than 200 prokaryotic (archaeal and bacterial) genomes have been completed and over 500 prokaryotic genomes are in va- ous stages of completion. Seventeen eukaryotic genomes plus four eukaryotic chro- somes have been completed. The concept of achieving better understanding of an organism through knowledge of the complete genomic sequence was first demonstrated in 1978 when the first bacteriophage genome, X174, was sequenced. Complete genomic sequences of prokaryotes have led to a better understanding of the biology and evolution of the microbes, and, for pathogens, facilitated identification of new vaccine candidates, putative virulence genes, targets for antibiotics, new strategy for rapid diagnosis, and investigation of bacteria–host interactions and disease mec- nisms. Recent increased interest in microbial pathogens and infectious diseases is largely attributed to the re-emergence of infectious diseases like tuberculosis, emergence of new infectious diseases like AIDS and severe acute respiratory syndrome, the problem of an increasing rate of emergence of antibiotic-resistant variants of pathogens, and the fear of bioterrorism. Microbes are highly diverse and abundant in the biosphere. Less than 1% of these morphologically identified microbes can be cultured in vitro using standard techniques and conditions. With such abundance of microbes in nature, we can expect to see new variants and new species evolve and a small number will emerge as pathogens to humans.
Reviews
"...should serve well those seeking a general introduction and overview of both the principles and application of microbial genomics to the study of infectious disease. Clear explanations of what can often be viewed as a complex and confusing subject should make this a valuable resource in this important and rapidly advancing area of research." -Doody's Book Review, Weighted Numberical Score: 78 - 3 stars
Editors and Affiliations
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Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada
Voon L. Chan
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Department of Paediatrics Department of Laboratory Medicine and Pathobiology Hospital for Sick Children, University of Toronto, Toronto, Canada
Philip M. Sherman
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Children’s Research Center, Our Lady’s Hospital for Sick Children, School of Medicine and Medical Science, Dublin, Ireland
Billy Bourke
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Conway Institute for Biomolecular and Biomedical Research, University College, Dublin, Ireland
Billy Bourke
