The Orexin/Hypocretin System

1. Front Matter

   Pages i-xii

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2. History

   1. Front Matter

      Pages 1-1

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   2. History and Overview of Orexin/Hypocretin Research

      • Michihiro Mieda, Takeshi Sakurai

      Pages 3-10

3. Overview of the Orexin/Hypocretin Neuronal System

   1. Front Matter

      Pages 11-11

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   2. Orexin and Orexin Receptors

      • Takeshi Sakurai

      Pages 13-20

   3. Orexin Projections and Localization of Orexin Receptors

      • Jacob N. Marcus, Joel K. Elmquist

      Pages 21-43

   4. Neuronal Responses to Hypocretin/Orexin

      • Anthony N. van den Pol, Claudio Acuna-Goycolea

      Pages 45-60

   5. Afferent System of Orexin Neurons

      • Akihiro Yamanaka

      Pages 61-70

4. Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids

   1. Front Matter

      Pages 71-71

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   2. Hypocretin Measurements in the CSF, and Blood and Brain Tissue

      • Seiji Nishino

      Pages 73-82

   3. Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTPγS Autoradiography

      • René Bernard, Ralph Lydic, Helen A. Baghdoyan

      Pages 83-96

5. Physiology

   1. Front Matter

      Pages 97-97

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   2. Orexin System and Feeding Behavior

      • Takeshi Sakurai

      Pages 99-106

   3. Orexins and the Autonomic Nervous System

      • Tetsuro Shirasaka, Masamitsu Nakazato

      Pages 107-117

   4. Neuroendocrine Role of the Orexins (Hypocretins)

      • Shahrad Taheri

      Pages 119-130

   5. The Orexin/Hypocretin System and Stress and Emotion

      • Yoichi Ueta, Hiroaki Fujihara

      Pages 131-140

6. Physiology

   1. Front Matter

      Pages 141-141

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   2. Hypocretin as a Wakefulness Regulatory Peptide

      • Luis de Lecea, J. Gregor Sutcliffe

      Pages 143-153

   3. Hypocretin/Orexin Tonus and Vigilance Control

      • Yasushi Yoshida, Seiji Nishino

      Pages 155-173

   4. Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance

      • Krister S. Eriksson, Helmut L. Haas

      Pages 175-188

Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations.
Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.

• Nervous System
• biological fluid
• clinical application
• neuroendocrinology
• neurons
• pathophysiology
• physiology
• tissue

• Center for Narcolepsy, Stanford University School of Medicine, Stanford

  Seiji Nishino

• Department of Pharmacology Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan

  Takeshi Sakurai

Policies and ethics