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Bone Metastasis

  • Book
  • © 2005

Overview

Editors:
  1. Gurmit Singh

    1. Department of Pathology and Molecular Medicine/Juravinski Cancer Centre, McMaster University, Hamilton, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Shafaat A. Rabbani

    1. Calcium Research Laboratory, McGill University Health Centre, Montreal, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Fundamental Concepts

    1. Front Matter

      Pages 1-1
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    2. Overview

      • Sadmeet Singh, Gurmit Singh
      Pages 3-12

    3. Parathyroid Hormone-Related Peptide and Malignancy

      • David Goltzman
      Pages 13-27

    4. Vitamin D and Vitamin D Analogs in Cancer Progression and Metastasis

      • Richard Kremer, Shafaat A. Rabbani
      Pages 29-57

    5. Role of TGF-β and IGF in Tumor Progression and Bone Metastases

      • Erin Giles, Gurmit Singh
      Pages 59-74

    6. Biologic and Therapeutic Implications of Osteomimicry and Epithelial-Mesenchymal Transition in Prostate Cancer

      • Wen-Chin Huang, Valerie Odero-Marah, Leland W. K. Chung
      Pages 75-86

    7. Roles of Immune-Cell-Derived Matrix Metalloproteinases in Tumor Growth and Metastasis

      • Kristina A. Szabo, Gurmit Singh
      Pages 87-106

    8. Contribution of Osteopontin to the Development of Bone Metastasis

      • Alison L. Allan, Alan B. Tuck, Vivien H. C. Bramwell, Theodore A. Vandenberg, Eric W. Winquist, Ann F. Chambers
      Pages 107-123

    9. Role of Interleukin-11 in Osteolytic Bone Metastasis

      • Ryan R. Simon, Martin K. Butcher, Stephen G. Shaughnessy
      Pages 125-132

    10. Cell Adhesion Molecules in Tumor Metastasis

      • Sujata Persad, Gurmit Singh
      Pages 133-146

    11. PTHrP and Cancer

      • Leonard J. Deftos, D. W. Burton, Randolph H. Hastings
      Pages 147-175

    12. Antithrombotics in Tumor Growth and Metastasis

      • Shaker A. Mousa
      Pages 177-187

  3. Therapeutic Strategies

    1. Front Matter

      Pages 189-189
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    2. Challenges and Strategies in the Analysis of Multiple Events in Oncology

      • Pierre P. Major, Richard J. Cook
      Pages 191-199

    3. Integrins

      • Graham C. Parry, Fernando Doñate, Marian L. Plunkett, David E. Shaw, Steven Pirie-Shepherd, Andrew P. Mazar
      Pages 201-227

    4. Bone Metastasis and Pathological Fractures

      • Laurie A. McDuffee, Nigel Colterjohn, Gurmit Singh
      Pages 229-241

    5. Role of Photodynamic Therapy for Bone Metastasis

      • Shane Burch, Albert J. M. Yee
      Pages 243-253

    6. Docetaxel for Metastatic Cancer and Its Role in Combination Therapies for Advanced Prostate Cancer

      • Ellen K. Wasan, Martin Gleave, Karen Fang, Kim Chi, Gwyn Bebb, Lincoln Edwards et al.
      Pages 255-292

    7. Use of Tetracyclines for Bone Metastases

      • Eric Seidlitz, Zeina Saikali, Gurmit Singh
      Pages 293-303
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Keywords

About this book

A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.

Editors and Affiliations

  • Department of Pathology and Molecular Medicine/Juravinski Cancer Centre, McMaster University, Hamilton, Canada

    Gurmit Singh

  • Calcium Research Laboratory, McGill University Health Centre, Montreal, Canada

    Shafaat A. Rabbani

Bibliographic Information

  • Book Title: Bone Metastasis

  • Editors: Gurmit Singh, Shafaat A. Rabbani

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1385/1592598927

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2005

  • Hardcover ISBN: 978-1-58829-403-6Published: 20 January 2005

  • Softcover ISBN: 978-1-61737-545-3Published: 19 November 2010

  • eBook ISBN: 978-1-59259-892-2Published: 28 October 2007

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XIII, 344

  • Topics: Oncology

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