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The Principles of Clinical Cytogenetics

  • Book
  • © 2005

Overview

Editors:
  1. Steven L. Gersen

    1. AmeriPath Inc., USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Martha B. Keagle

    1. School of Allied Health Professions, University of Connecticut, Storrs

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Basic Concepts and Background

    1. Front Matter

      Pages 1-1
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    2. History of Clinical Cytogenetics

      • Steven L. Gersen
      Pages 3-8

    3. DNA, Chromosomes, and Cell Division

      • Martha B. Keagle
      Pages 9-25

    4. Human Chromosome Nomenclature

      • Avirachan Tharapel
      Pages 27-57

  3. Examining and Analyzing Chromosomes

    1. Front Matter

      Pages 59-59
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    2. Basic Laboratory Procedures

      • Martha B. Keagle, Steven L. Gersen
      Pages 63-79

    3. The Fundamentals of Microscopy

      • Christopher McAleer
      Pages 81-91

    4. Quality Control and Quality Assurance

      • Michael S. Watson, Steven L. Gersen
      Pages 93-112

    5. Instrumentation in the Cytogenetics Laboratory

      • Steven L. Gersen, Lotte Downey
      Pages 113-130

  4. Clinical Cytogenetics

    1. Front Matter

      Pages 131-131
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    2. Autosomal Aneuploidy

      • Jin-Chen C. Wang
      Pages 133-164

    3. Structural Chromosome Rearrangements

      • Kathleen Kaiser-Rogers, Kathleen Rao
      Pages 165-206

    4. Sex Chromosomes and Sex Chromosome Abnormalities

      • Cynthia M. Powell
      Pages 207-246

    5. Cytogenetics of Infertility

      • Linda Marie Randolph
      Pages 247-265

    6. Prenatal Cytogenetics

      • Linda Marie Randolph
      Pages 267-321

    7. Cytogenetics of Spontaneous Abortion

      • Solveig M. V. Pflueger
      Pages 323-345

    8. Chromosome Instability

      • Xiao-Xiang Zhang
      Pages 347-361

  5. Cancer Cytogenetics

    1. Front Matter

      Pages 363-363
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    2. Cytogenetics of Hematologic Neoplasms

      • Rizwan C. Naeem
      Pages 365-420
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Keywords

About this book

In the summer of 1989, one of us (SLG), along with his mentor, Dorothy Warb- ton, attended the Tenth International Workshop on Human Gene Mapping. The me- ing was held at Yale University in celebration of the first such event, which also took place there. This meeting was not open to the general public; one had to have contributed to mapping a gene to be permitted to attend. The posters, of course, were therefore all related to gene mapping, and many were covered with pretty, colorful pictures of a novel, fluorescent application of an old technology, in situ hybridization. Walking through the room, Dorothy remarked that, because of this new FISH technique, ch- mosomes, which had become yesterday’s news, were once again “back in style. ” Approximately three years later, a commercial genetics company launched a FISH assay for prenatal ploidy detection. A substantial number of cytogeneticists across the country reacted with a combination of outrage and panic. Many were concerned that physicians would be quick to adopt this newfangled upstart test and put us all on the unemployment line. They did not at the time realize what Dorothy instinctively already knew—that FISH would not spell the doom of the cytogenetics laboratory, but it would, rather, take it to new heights.

Reviews

From Reviews of the First Edition...

"...an excellent comprehensive review of the basic concepts of clinical cytogenetics...recommended for any medical specialty that utilizes cytogenetic testing." -Modern Pathology

"...a good grounding for anyone with a general interest in the subject..." -Human Genetics

"...a real contribution to the field...should be a permanent resource not only for cytogeneticists, but also for doctors active in hematology and oncology, clinical pathologists, and perinatal specialists." -Laboratoriums Medezin

"...an up-to-date window into the recent advances in cytogenetics, both molecular and clinical...recommended even for those who already have the first edition." - Journal of the Association of Genetic Technologists

Editors and Affiliations

  • AmeriPath Inc., USA

    Steven L. Gersen

  • School of Allied Health Professions, University of Connecticut, Storrs

    Martha B. Keagle

Bibliographic Information

  • Book Title: The Principles of Clinical Cytogenetics

  • Editors: Steven L. Gersen, Martha B. Keagle

  • DOI: https://doi.org/10.1385/1592598331

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2005

  • eBook ISBN: 978-1-59259-833-5Published: 17 August 2008

  • Edition Number: 2

  • Number of Pages: XIII, 596

  • Topics: Human Genetics, Pathology

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