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The Molecular Basis of Human Cancer

  • Book
  • © 2002

Overview

Editors:
  1. William B. Coleman

    1. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Gregory J. Tsongalis

    1. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xii
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Cancer Epidemiology

      • William B. Coleman, Gregory J. Tsongalis
      Pages 3-22

  3. Essential Concepts in Molecular Biology

    1. Front Matter

      Pages 23-23
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    2. Essential Concepts and Techniques in Molecular Biology

      • Sharon Collins Presnell
      Pages 25-42

  4. Molecular Themes in Oncogenesis

    1. Front Matter

      Pages 43-43
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    2. Cancer Genes

      • John J. Reinartz
      Pages 45-64

    3. Positive Mediators of Cell Proliferation in Neoplastic Transformation

      • James N. Welch, Susan A. Chrysogelos
      Pages 65-79

    4. Inactivation of Negative Growth Regulators During Neoplastic Transformation

      • Kara N. Smolinski, Stephen J. Meltzer
      Pages 81-111

  5. Mechanisms of Mutation

    1. Front Matter

      Pages 113-113
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    2. The Role of Genomic Instability in the Development of Human Cancer

      • William B. Coleman, Gregory J. Tsongalis
      Pages 115-142

    3. Chromosomes and Chromosomal Instability in Human Cancer

      • Takashi Shimamoto, Kazuma Ohyashiki
      Pages 143-158

    4. Hereditary Cancer

      • Bruce M. Boman, Lael Melchert, Jeremy Z. Fields
      Pages 159-185

  6. Etiology of Human Cancers

    1. Front Matter

      Pages 187-187
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    2. Evolution of Research in Cancer Etiology

      • Lorenzo Tomatis, James Huff
      Pages 189-201

    3. Cellular Responses to Chemical Carcinogens

      • Edward L. Loechler, Bryan Henry, Kwang-Young Seo
      Pages 203-222

    4. Physical Agents in Human Carcinogenesis

      • Cynthia R. Timblin, Yvonne Janssen-Heininger, Brooke T. Mossman
      Pages 223-232

    5. Viral Mechanisms of Human Carcinogenesis

      • Felix Hoppe-Seyler, Karin Butz
      Pages 233-247

  7. Human Tumor Systems

    1. Front Matter

      Pages 249-249
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    2. The Molecular Biology of Colorectal Carcinoma

      • J. Milburn Jessup, Gary Gallick, Bo Liu
      Pages 251-268
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Keywords

About this book

Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.

Reviews

"The structure of the book is fairly conventional, with an excellent scene-setting chapter that provides a clear description of widely applied methodologies....The tumor-specific chapters are well written and will attract those with interests in particular tumor-types. The colorectal chapters is especially well written, focussing on how the genetic alterations lead to changes in signal transduction pathways, which underpin disordered growth regulation. All chapters are extensively referenced....the book is well written and should be useful to fellows just about to enter the laboratory to undertake a period of molecular research, and for those established clinicians who require a detailed update on the contribution that molecular biology has made to cancer research." - Annals of Oncology

"This is an excellent volume for both investigators in the field of oncology as well as practicing oncologists." -Quarterly Review of Biology

Editors and Affiliations

  • Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, USA

    William B. Coleman

  • Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, USA

    Gregory J. Tsongalis

Bibliographic Information

  • Book Title: The Molecular Basis of Human Cancer

  • Editors: William B. Coleman, Gregory J. Tsongalis

  • DOI: https://doi.org/10.1007/978-1-59259-125-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Softcover ISBN: 978-1-61737-107-3Published: 05 November 2010

  • eBook ISBN: 978-1-59259-125-1Published: 10 August 2001

  • Edition Number: 1

  • Number of Pages: XII, 588

  • Topics: Oncology

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