Overview
- Provides cutting edge methods for in vitro and in vivo studies of nucleic acid based drugs
- Presents detailed protocols for preparation of non-viral drug delivery vehicles and artificial membrane models
- Includes a comprehensive description of retrieval of internalizing antibodies from phage display libraries
- Gives step-by-step methods for in vitro and in vivo studies of macromolecular delivery across biological barriers
Part of the book series: Methods in Molecular Biology (MIMB, volume 480)
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Table of contents (14 protocols)
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Front Matter
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Back Matter
Keywords
About this book
Macromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.
Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases.
Reviews
From the reviews:
"This volume … provides details and discussions on contemporary methods available to address the limitations in the delivery of these agents. … This comprehensive review will be of interest to scientists investigating either the in vitro or in vivo actions of macromolecule agents. Experts in biophysics, chemistry, cell biology, pharmaceutics, and/or preclinical and clinical dug discovery studies will find this book of value. Researchers involved in target therapy strategies for treatment of diseases will want a copy of this book." (Thomas L. Pazdernik, Doody’s Review Service, 2009)
“The title of the book will definitely attract readers of various backgrounds. It seems to indicate that the book covers the delivery of various kinds of macromolecular drugs. … This will come as a surprise for experts working with other types of macromolecular therapeutics … . the in vitro and in vivo models described in the book would be of interest to a broad scientific audience. … the book definitely contains a lot of valuable information for experimental researchers.” (Michal Pechar, ChemMedChem, Issue 4, 2009)Bibliographic Information
Book Title: Macromolecular Drug Delivery
Book Subtitle: Methods and Protocols
Editors: Mattias Belting
Series Title: Methods in Molecular Biology
DOI: https://doi.org/10.1007/978-1-59745-429-2
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Humana Press 2009
Hardcover ISBN: 978-1-58829-999-4Published: 23 October 2008
Softcover ISBN: 978-1-62703-966-6Published: 30 October 2014
eBook ISBN: 978-1-59745-429-2Published: 16 December 2008
Series ISSN: 1064-3745
Series E-ISSN: 1940-6029
Edition Number: 1
Number of Pages: XIV, 205
Topics: Pharmacology/Toxicology, Biochemical Engineering, Pharmacy