Overview
- Editors:
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Joyce Tombran-Tink
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Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, USA
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Colin J. Barnstable
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Department of Neural andBehavioral Sciences, Penn State University College of Medicine, Hershey, USA
- Focuses on the molecular characteristics, localization, and substrate specificities of several classes of well-known membrane transporters in various compartments of the eye
- Illustrates how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness
- Examines how epithelial and endothelial barriers can block drug delivery and limit ocular availability of drugs
- Includes supplementary material: sn.pub/extras
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Table of contents (24 chapters)
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Front Matter
Pages i-xviii
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Transport in the Anterior Segment
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- Peter S. Reinach, José E. Capó-Aponte, Stefan Mergler, Kathryn S. Pokorny
Pages 17-46
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- Ram Kannan, Hovhannes J. Gukasyan
Pages 47-57
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Transporters of the Ciliary Epithelium
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- Chi-wai Do, Chi-wing Kong, Chu-yan Chan, Mortimer M. Civan, Chi-ho To
Pages 61-86
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Lens Transporters
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- Paul J. Donaldson, Julie Lim
Pages 89-110
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- Nicholas A. Delamere, Shigeo Tamiya
Pages 111-123
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Transport Across the Blood–Retinal Barrier
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- Masatoshi Tomi, Ken-ichi Hosoya
Pages 139-154
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Transport Across the Retinal Pigment Epithelium
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- Adnan Dibas, Thomas Yorio
Pages 157-184
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- Ali A. Hussain, John Marshall
Pages 217-233
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- Paul A. Constable, John G. Lawrenson, N. Joan Abbott
Pages 235-253
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Transporters in the Retina
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- Paul P. M. Schnetkamp, Yoskiyuki Shibukawa, Haider F. Altimimi, Tashi G. Kinjo, Pratikhya Pratikhya, Kyeong Jing Kang et al.
Pages 257-273
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Genetic Variants of Ocular Transporters
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- Nigel L. Barnett, Natalie D. Bull
Pages 333-353
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- Erica L. Fletcher, Michelle M. Ward
Pages 355-371
About this book
Detection and responses to light are common features found throughout the plant and animal kingdoms. In most primitive life forms, a patch of light-sensitive cells make up a region containing a cell sheet devoid of any specialized anatomical structure. With the development of the eyes in more advanced life forms, light-sensing structures became more complex but primitive eyes are still in contiguity with other body tissues and fluids. The evolution of the eyeball promoted an increase in visual acuity and visual processing that, in turn, allowed vision to become the dominant sensory system for many species, including humans. The formation of a totally enclosed structure, however, required a unique set of solutions to enable the eye to control its environment. Like most organs, the eye evolved a series of homeostatic mechanisms to regulate its environment within tightly controlled limits. Unlike most organs, however, this advanced light-sensing structure has a series of requirements that place a tremendous burden on molecules that are responsible for controlling ocular homeostasis. There are many sig naling molecules and pathways that work in parallel or through crosstalk to maintain the normal ocular environment required for visual function. Perhaps none are so critical as the group of membrane molecules that are collectively termed transporters. These molecules are responsible for the controlled and selective movements of ions, nutrients, and fluid across various ocular layers necessary to optimize the internal milieu to p- serve visual function.
Reviews
From the reviews:
“The ophthalmic structures and tissues present a series of mechanisms necessary to homeostasis maintenance, in order to enable and support the vision function. … this book is indicated for physicians, pharmacologists, pharmacotechnicians, and investigators who wish to understand and study the complex processes of transportation and homeostasis of ocular globe, as well as to develop and formulate eye drops or apply therapies in the ophthalmology area.” (Vladi Olga Consiglieri, Brazilian Journal of Pharmaceutical Sciences, 2009)
Editors and Affiliations
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Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, USA
Joyce Tombran-Tink
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Department of Neural andBehavioral Sciences, Penn State University College of Medicine, Hershey, USA
Colin J. Barnstable
About the editors
Colin J. Barnstable, D.Phil., is Professor and Chair, Department of Neural and Behavioral Sciences
Director, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute
Joyce Tombran-Tink, PhD, Department of Neural and Behavioral Sciences, Penn State Hershey Neuroscience Research Institute and Co-Director, Penn State Neuroscience Institute
