Overview
- First book to summarize recent advances in identifying components of cell-cycle checkpoints and validating the use of checkpoint proteins as targets for the development of anticancer drugs
- Distinguished authors write on topics that range from the molecular players affecting DNA synthesis and the response to DNA damage, to advances in the identification of inhibitors for individual mitotic kinases
- Offers a summary of their findings for researchers in the pharmaceutical and biotechnology industries
- Valuable resource for cancer researchers studying of cell-cycle regulation, signal transduction, and apoptosis
Part of the book series: Cancer Drug Discovery and Development (CDD&D)
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Table of contents (13 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.
Editors and Affiliations
Bibliographic Information
Book Title: Checkpoint Responses in Cancer Therapy
Editors: Wei Dai
Series Title: Cancer Drug Discovery and Development
DOI: https://doi.org/10.1007/978-1-59745-274-8
Publisher: Humana Totowa, NJ
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Humana Press 2008
Hardcover ISBN: 978-1-58829-930-7Published: 06 June 2008
Softcover ISBN: 978-1-61737-847-8Published: 19 November 2010
eBook ISBN: 978-1-59745-274-8Published: 01 May 2008
Series ISSN: 2196-9906
Series E-ISSN: 2196-9914
Edition Number: 1
Number of Pages: XIV, 314
Number of Illustrations: 30 b/w illustrations, 3 illustrations in colour
Topics: Cancer Research, Pharmacology/Toxicology