Overview
- Features novel drug targets including peptide deformylase, ribosome formation, lipopolysaccharide and fatty acid biosynthesis and signal transduction pathways.
- Includes new methods for the assay of RNA polymerase, peptide bond formation, translational initiation, ribosome biogenesis and membrane permeability, as well as methods for target identification by bacterial genome searches
- Details the activity of novel inhibitors of DNA polymerase, peptide deformylase, membrane transport, efflux pumps and beta-lactamases
Part of the book series: Methods in Molecular Medicine (MIMM, volume 142)
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Table of contents (20 protocols)
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Front Matter
Keywords
About this book
A crisis is developing in the treatment of infectious diseases, with microorganisms frequently showing resistance to currently prescribed antibiotics. Fewer and fewer antimicrobial agents are now available to treat these infections. In “New Antibiotic Targets,” W. Scott Champney examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies.
“New Antibiotic Targets” provides laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.
Reviews
From the reviews:
"This book describes, in specific detail, a variety of methods used to identify cellular components of bacteria that would be good targets for antibiotics. … Those working in laboratories on discovery of new antibiotics are the intended audience. The book is easy to follow and written in a step-wise fashion. It would be easy for laboratory technicians as well as graduate students to follow. … This is a good methods book that contains the latest information on new techniques." (Rebecca T. Horvat, Doody’s Review Service, May, 2008)
"The contributors to each chapter are good and well known names in their fields, providing good coverage of their subjects. I think this book will find utility in the field of drug discovery and target identification specifically from compound libraries … ." (Paul Hoskisson, Microbiology Today, July, 2008)
Editors and Affiliations
Bibliographic Information
Book Title: New Antibiotic Targets
Editors: W. Scott Champney
Series Title: Methods in Molecular Medicine
DOI: https://doi.org/10.1007/978-1-59745-246-5
Publisher: Humana Totowa, NJ
eBook Packages: Springer Protocols
Copyright Information: Humana Press 2008
Hardcover ISBN: 978-1-58829-915-4Published: 15 January 2008
Softcover ISBN: 978-1-61737-843-0Published: 10 November 2010
eBook ISBN: 978-1-59745-246-5Published: 01 February 2008
Series ISSN: 1543-1894
Series E-ISSN: 1940-6037
Edition Number: 1
Number of Pages: XII, 274
Number of Illustrations: 51 b/w illustrations
Topics: Infectious Diseases, Immunology, Molecular Medicine, Virology