Transforming Growth Factor-Beta in Cancer Therapy, Volume II

1. Front Matter

   Pages i-xxvi

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2. Transforming Growth Factor-β In Developing and Advanced Cancers

   1. Front Matter

      Pages 1-1

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   2. Transforming Growth Factor-β Signaling in Pancreas Development and Pancreatic Disease

      • Sushil G. Rane, Huei-Min Lin, Ji-Hyeon Lee

      Pages 3-19

   3. Role of Transforming Growth Factor-β in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma

      • Stephen M. Weber, Shi-Long Lu, Sophia Bernstein, Xiao-Jing Wang

      Pages 21-32

   4. TGF-β, Smads and Cervical Cancer

      • Devarajan Karunagaran, Goodwin Jinesh

      Pages 33-49

   5. TGF-β Signaling and Biglycan in Pancreatic Cancer

      • Hendrik Ungefroren

      Pages 51-62

   6. TGF-β Signaling in Endometrial Cancer

      • Dagmara Piestrzeniewicz-Ulanska, David H. McGuinness, Grant R. Yeaman

      Pages 63-78

   7. TGF-β Ligands, TGF-β Receptors, and Lung Cancer

      • Guiying Y. Wang, Xiaochua H. Hu, Rongmei M. Zhang, Lindsey J. Leach, Zewei W. Luo

      Pages 79-93

   8. Role of TGF-β in Osteolytic Bone Metastases

      • Laurent Bartholin, Theresa Guise

      Pages 95-123

   9. Hormonal Regulation of Transforming Growth Factor-β in Breast Cancer

      • Miriam Buck, Cornelius Knabbe

      Pages 125-132

   10. TGF-β and Progression of Esophageal Cancer

       • Minoru Fukuchi, Hiroyuki Kato, Hiroyuki Kuwano

       Pages 133-140

   11. TGF-β and HER2/ErbB2 and Breast Cancer Progression

       • Nataša Todorović-Raković

       Pages 141-151

   12. TGF-β Dependent T-Cell Regulation in Colitis and Colon Cancer

       • Christoph Becker, Markus F. Neurath

       Pages 153-166

   13. Role of Transforming Growth Factor-β in the Kidney — Physiology and Pathology

       • Elena Gagliardini, Ariela Benigni

       Pages 167-179

   14. Perturbations of TGF-β Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis

       • Lawrence A. Wolfraim, John J. Letterio

       Pages 181-202

   15. Transforming Growth Factor-β in Brain Functions and Dysfunctions

       • Denis Vivien, Karim Benchenane, Carine Ali

       Pages 203-218

   16. Inhibition of TGF-β Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment

       • Hiroshi Yasui, Teru Hideshima, Kenneth C. Anderson

       Pages 219-227

   17. Key Roles of TGF-β and Smad3 in Prostate Cancer

       • Kyung Song, David Danielpour

       Pages 229-246

   18. Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-β Type I Receptor

       • Francis Ruscetti, Salem Akel, Maria Birchenall-Roberts, Zhouhong Cao, Anita B. Roberts

       Pages 247-261

3. Transforming Growth Factor-β in Cancer Treatment and Therapy

   1. Front Matter

      Pages 263-263

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Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim­ ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.

• Activation
• DNA
• Endoplasmatisches Reticulum
• Vivo
• angiogenesis
• carcinoma
• gene transfer
• genes
• leukocytes
• positron emission tomography
• regulation
• tissue
• translation
• tumor growth
• tumorigenesis

From the reviews:

"This volume … provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. … This will likely be of interest to those in the field as well as those who are new … . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. … This will be a great resource for researchers and clinicians … ." (James P Luyendyk, Doody’s Review Service, June, 2008)

• Cancer Training Branch, Office of Centers, Training and Resources, National Cancer Institute, Bethesda

  Sonia B. Jakowlew

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