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Transforming Growth Factor-Beta in Cancer Therapy, Volume II

Cancer Treatment and Therapy

  • Book
  • © 2008

Overview

Editors:
  1. Sonia B. Jakowlew

    1. Cancer Training Branch, Office of Centers, Training and Resources, National Cancer Institute, Bethesda

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  • Details the role of TGF- ß in cancer treatment and therapy, including its role in development and progression of several different cancers
  • Conveniently divided into three easy-to-follow parts
  • Companion volume details the role of TGF- ß on basic and clinical biology

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (46 chapters)

  1. Front Matter

    Pages i-xxvi
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  2. Transforming Growth Factor-β In Developing and Advanced Cancers

    1. Front Matter

      Pages 1-1
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    2. Transforming Growth Factor-β Signaling in Pancreas Development and Pancreatic Disease

      • Sushil G. Rane, Huei-Min Lin, Ji-Hyeon Lee
      Pages 3-19

    3. Role of Transforming Growth Factor-β in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma

      • Stephen M. Weber, Shi-Long Lu, Sophia Bernstein, Xiao-Jing Wang
      Pages 21-32

    4. TGF-β, Smads and Cervical Cancer

      • Devarajan Karunagaran, Goodwin Jinesh
      Pages 33-49

    5. TGF-β Signaling and Biglycan in Pancreatic Cancer

      • Hendrik Ungefroren
      Pages 51-62

    6. TGF-β Signaling in Endometrial Cancer

      • Dagmara Piestrzeniewicz-Ulanska, David H. McGuinness, Grant R. Yeaman
      Pages 63-78

    7. TGF-β Ligands, TGF-β Receptors, and Lung Cancer

      • Guiying Y. Wang, Xiaochua H. Hu, Rongmei M. Zhang, Lindsey J. Leach, Zewei W. Luo
      Pages 79-93

    8. Role of TGF-β in Osteolytic Bone Metastases

      • Laurent Bartholin, Theresa Guise
      Pages 95-123

    9. Hormonal Regulation of Transforming Growth Factor-β in Breast Cancer

      • Miriam Buck, Cornelius Knabbe
      Pages 125-132

    10. TGF-β and Progression of Esophageal Cancer

      • Minoru Fukuchi, Hiroyuki Kato, Hiroyuki Kuwano
      Pages 133-140

    11. TGF-β and HER2/ErbB2 and Breast Cancer Progression

      • NataÅ¡a Todorović-Raković
      Pages 141-151

    12. TGF-β Dependent T-Cell Regulation in Colitis and Colon Cancer

      • Christoph Becker, Markus F. Neurath
      Pages 153-166

    13. Role of Transforming Growth Factor-β in the Kidney — Physiology and Pathology

      • Elena Gagliardini, Ariela Benigni
      Pages 167-179

    14. Perturbations of TGF-β Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis

      • Lawrence A. Wolfraim, John J. Letterio
      Pages 181-202

    15. Transforming Growth Factor-β in Brain Functions and Dysfunctions

      • Denis Vivien, Karim Benchenane, Carine Ali
      Pages 203-218

    16. Inhibition of TGF-β Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment

      • Hiroshi Yasui, Teru Hideshima, Kenneth C. Anderson
      Pages 219-227

    17. Key Roles of TGF-β and Smad3 in Prostate Cancer

      • Kyung Song, David Danielpour
      Pages 229-246

    18. Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-β Type I Receptor

      • Francis Ruscetti, Salem Akel, Maria Birchenall-Roberts, Zhouhong Cao, Anita B. Roberts
      Pages 247-261

  3. Transforming Growth Factor-β in Cancer Treatment and Therapy

    1. Front Matter

      Pages 263-263
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Keywords

About this book

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim­ ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.

Reviews

From the reviews:

"This volume … provide readers with a detailed account of the role of TGF-beta in the development of various cancers in numerous organs. … This will likely be of interest to those in the field as well as those who are new … . will be of interest to researchers at all levels. The book will likely attract new researchers and students interested in becoming engaged in new frontiers of cancer therapy. … This will be a great resource for researchers and clinicians … ." (James P Luyendyk, Doody’s Review Service, June, 2008)

Editors and Affiliations

  • Cancer Training Branch, Office of Centers, Training and Resources, National Cancer Institute, Bethesda

    Sonia B. Jakowlew

Bibliographic Information

  • Book Title: Transforming Growth Factor-Beta in Cancer Therapy, Volume II

  • Book Subtitle: Cancer Treatment and Therapy

  • Editors: Sonia B. Jakowlew

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59745-293-9

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-715-0Published: 28 February 2008

  • Softcover ISBN: 978-1-61737-736-5Published: 19 November 2010

  • eBook ISBN: 978-1-59745-293-9Published: 01 January 2010

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XXVI, 786

  • Number of Illustrations: 160 b/w illustrations, 4 illustrations in colour

  • Topics: Oncology, Cancer Research, Cell Biology, Pathology

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