Polyamine Cell Signaling

1. Front Matter

   Pages i-xiv

   PDF

2. Polyamines in Signal Transduction of Cell Proliferation

   1. Front Matter

      Pages 1-1

      PDF

   2. Polyamine Structure and Synthetic Analogs

      • Patrick M. Woster

      Pages 3-24

   3. Acute Increases in Intracellular Putrescine Lead to the Increase in Steady-State Levels of c-fos, c-jun, RING3, and Id-1 mRNAs

      • Allan A. Ancheta, Leo Hawel III, Craig V. Byus

      Pages 25-40

   4. Polyamine-Dependent Early Cellular Signals and Cell Proliferation

      • Stina M. Oredsson

      Pages 41-50

   5. Cellular Signals Mediating Growth Arrest After Polyamine Depletion

      • Jian-Ying Wang

      Pages 51-73

   6. Role of Polyamines in the Regulation of Chromatin Acetylation

      • Cheryl A. Hobbs, Susan K. Gilmour

      Pages 75-89

   7. Role of Polyamines in Regulation of Sequence-Specific DNA Binding Activity

      • Sripriya Venkiteswaran, Thresia Thomas, T. J. Thomas

      Pages 91-122

   8. Polyamine Metabolism and the Hypertrophic Heart

      • Lisa M. Shantz, Emanuele Giordano

      Pages 123-137

   9. Influence of Polyamines on Breast Cancer Biology

      • Andrea Manni

      Pages 139-153

   10. Polyamines in Regulation of Prostatic Cell Growth

       • Raymond G. Schipper, Vincent Cuijpers, Johannes C. Romijn, Albert A. J. Verhofstad

       Pages 155-168

   11. Polyamines in Kidney Biology

       • Joseph Satriano

       Pages 169-186

   12. Polyamines in Pulmonary Vascular Biology

       • Jack W. Olson, Mark N. Gillespie

       Pages 187-202

3. Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy

   1. Front Matter

      Pages 203-203

      PDF

   2. Recent Advances in the Understanding of Mammalian Polyamine Catabolism

      • Robert A. Casero Jr., Alison V. Fraser, Tracy Murray-Stewart, Amy Hacker, Naveen Babbar, Jennifer Fleischer et al.

      Pages 205-232

   3. Cellular Signaling and Polyamines in the Control of Apoptosis in Intestinal Epithelial Cells

      • Leonard R. Johnson, Ramesh M. Ray

      Pages 233-248

   4. The Role of Ornithine Decarboxylase in Myc-Induced Tumorigenesis

      • Jonas A. Nilsson, John L. Cleveland

      Pages 249-266

   5. Protective Effect of Polyamines on NSAID-Induced Injury and Apoptosis

      • Heather M. Wallace, Alun Hughes

      Pages 267-278

   6. Role of Polyamines in the Control of the Immune Response in the Brain

      • Denis Soulet, Serge Rivest

      Pages 279-292

   7. Implication of Polyamines in Apoptosis of Immunoresponse Cells

      • Rupesh Chaturvedi, Keith T. Wilson

      Pages 293-312

Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell–Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.

• DNA
• apoptosis
• biological functions
• influence
• physiology
• regulation
• signal transduction
• tumorigenesis

• Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore

  Jian-Ying Wang

• The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore

  Robert A. Casero

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