Overview
- Novel therapeutic concepts based on AML cell biology
- Critical factors in leukemia cell survival and drug resistance, and their potential exploitation as therapeutic targets
Part of the book series: Contemporary Hematology (CH)
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Table of contents (20 chapters)
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Front Matter
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Overview of AML
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Front Matter
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Molecular Foundations of AML Pathogenesis and Physiology
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Front Matter
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Translating Biology into Clinical Application
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Front Matter
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Molecular Therapeutics of AML: Selected Targeted Approaches
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Front Matter
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Keywords
About this book
Acute Myelogenous Leukemia is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation. There is an emphasis throughout on the bidirectional flow of knowledge between the clinical and laboratory arenas, and both basic and clinical scientists will benefit from this translational text.
Reviews
From the reviews:
"...warmly recommend this book as a comprehensive, up-to-date, and detailed yet concise source of information about AML." -The New England Journal of Medicine
"Acute Myelogenous Leukemia, edited by Judith E. Karp, MD, of Johns Hopkins University, is a multiauthored textbook directed towards the hematologist managing acute leukemia … . It focuses on new approaches, both practical and theoretical, based on laboratory data as well as clinical studies. … This textbook includes up-to-date, well-referenced chapters … . It is a welcomed edition to provide specific information and reference data for hematologists who specialize in AML management." (Barry Cooper, Baylor University Medical Center Proceedings, Vol. 21 (1), 2008)
"The book begins with an overview of the disease and ends with a chapter on some of the particular challenges faced by clinicians … . For clinicians involved in investigation of new agents, there is considerable usefulness … . In Acute Myelogenous Leukemia, the reader will find reviews of some of the newer agents and treatment strategies for this uncommon but devastating disease. In addition, this is a reliable source for thorough and clearly written explanations of the scientific development of these new agents." (Laura C. Michaelis, Journal of the American Medical Association, November, 2007)
Editors and Affiliations
Bibliographic Information
Book Title: Acute Myelogenous Leukemia
Editors: Judith E. Karp
Series Title: Contemporary Hematology
DOI: https://doi.org/10.1007/978-1-59745-322-6
Publisher: Humana Totowa, NJ
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Humana Press 2007
Hardcover ISBN: 978-1-58829-621-4Published: 12 June 2007
Softcover ISBN: 978-1-61737-675-7Published: 09 November 2010
eBook ISBN: 978-1-59745-322-6Published: 29 November 2009
Edition Number: 1
Number of Pages: XIV, 426
Number of Illustrations: 41 b/w illustrations, 14 illustrations in colour
Topics: Hematology, Oncology, Cancer Research, Internal Medicine