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Histone Deacetylases

Transcriptional Regulation and Other Cellular Functions

  • Book
  • © 2006

Overview

Editors:
  1. Eric Verdin

    1. Gladstone Institute of Virology and Immunology, University of California, San Francisco

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xi
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  2. Class I Histone Deacetylases

    1. Front Matter

      Pages 1-1
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    2. Histone Deacetylase 1

      • Dominique Meunier, Christian Seiser
      Pages 3-22

    3. Biochemistry of Multiprotein HDAC Complexes

      • Alejandro Vaquero, Michael Scher, Danny Reinberg
      Pages 23-60

    4. The Biology of HDAC3

      • Edward Seto
      Pages 61-86

    5. The Biology of HDAC8, a Unique Class I Histone Deacetylase

      • David Waltregny, Vincent Castronovo
      Pages 87-104

  3. Class II Histone Deacetylases

    1. Front Matter

      Pages 105-105
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    2. Regulation of Muscle Gene Expression by Histone Deacetylases

      • Timothy A. McKinsey, Eric N. Olson
      Pages 107-128

    3. The Class IIa Histone Deacetylases

      • Herbert G. Kasler, Eric Verdin
      Pages 129-163

    4. Histone Deacetylases in the Response to Misfolded Proteins

      • J. Andrew McKee, Tso-Pang Yao
      Pages 165-180

  4. Class III Histone Deacetylases

    1. Front Matter

      Pages 181-181
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    2. Evolution of Sirtuins From Archaea to Vertebrates

      • Roy A. Frye
      Pages 183-202

    3. Structure of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases

      • Kehao Zhao, Ronen Marmorstein
      Pages 203-217

    4. The Enzymology of SIR2 Proteins

      • Margie T. Borra, John M. Denu
      Pages 219-235

    5. The Class III Protein Deacetylases

      • Bjoern Schwer, Brian J. North, Nidhi Ahuja, Brett Marshall, Eric Verdin
      Pages 237-268

  5. Histone Deacetylase Inhibitors

    1. Front Matter

      Pages 269-269
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    2. HDAC Inhibitors

      • Akihiro Ito, Norikazu Nishino, Minoru Yoshida
      Pages 271-297

    3. Cell Cycle Targets of Histone Deacetylase Inhibitors

      • Brian Gabrielli
      Pages 299-313

    4. HDAC Inhibitors

      • Paul Kwon, Meier Hsu, Dalia Cohen, Peter Atadja
      Pages 315-332

  6. Back Matter

    Pages 333-340
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Keywords

About this book

A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.

Editors and Affiliations

  • Gladstone Institute of Virology and Immunology, University of California, San Francisco

    Eric Verdin

Bibliographic Information

  • Book Title: Histone Deacetylases

  • Book Subtitle: Transcriptional Regulation and Other Cellular Functions

  • Editors: Eric Verdin

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1385/1597450243

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2006

  • Hardcover ISBN: 978-1-58829-499-9Published: 05 January 2006

  • Softcover ISBN: 978-1-61737-602-3Published: 19 November 2010

  • eBook ISBN: 978-1-59745-024-9Published: 06 November 2007

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: 352

  • Number of Illustrations: 62 b/w illustrations, 1 illustrations in colour

  • Topics: Cancer Research

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