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The Adrenergic Receptors

In the 21st Century

  • Book
  • © 2006

Overview

Editors:
  1. Dianne M. Perez

    1. Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland

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Part of the book series: The Receptors (REC)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi
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  2. Historical Perspectives

    1. Front Matter

      Pages 1-1
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    2. Adrenergic Receptors

      • David B. Bylund
      Pages 3-21

  3. Structure-Function

    1. Front Matter

      Pages 23-23
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    2. Ligand Binding, Activation, and Agonist Trafficking

      • Angela M. Finch, Valerie Sarramegna, Robert M. Graham
      Pages 25-85

    3. New Signal Transduction Paradigms

      • Kenneth P. Minneman
      Pages 87-106

    4. Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors

      • Michael T. Piascik, Mary Lolis García-Cazarin, Steven R. Post
      Pages 107-128

    5. Adrenergic Receptors in Clinical Medicine

      • Martin C. Michel, Paul A. Insel
      Pages 129-147

  4. Imaging Adrenergic Receptors and Their Function

    1. Front Matter

      Pages 149-149
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    2. Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors

      • John C. McGrath, Craig J. Daly
      Pages 151-172

    3. Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors

      • Dianne M. Perez
      Pages 173-204

  5. Genetically Altered Mouse Models

    1. Front Matter

      Pages 205-205
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    2. The α1-Adrenergic Receptors

      • Paul C. Simpson
      Pages 207-240

    3. The α2-Adrenergic Receptors

      • Christopher M. Tan, Lee E. Limbird
      Pages 241-265

    4. The β-Adrenergic Receptors

      • Yang Xiang, Brian Kobilka
      Pages 267-291

    5. Lessons From Overexpressed Mouse Models

      • Cinzia Perrino, Liza Barki-Harrington, Howard A. Rockman
      Pages 293-320

    6. Adrenergic Receptor Signaling Components in Gene Therapy

      • Andrea D. Eckhart, Walter J. Koch
      Pages 321-335

  6. Pharmacogenomics

    1. Front Matter

      Pages 337-337
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    2. Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms

      • Stephen B. Liggett
      Pages 339-364

    3. Microarray Analysis of Novel Adrenergic Receptor Functions

      • Boyd Rorabaugh, June Yun, Dianne M. Perez
      Pages 365-391
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Keywords

About this book

An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.

Reviews

From the reviews:

"...useful to anyone interested in adrenoceptor physiology/pharmacology or in the design of drugs interacting with the receptor or its signal transduction pathway." -Journal of Medicinal Chemistry

"Dianne Perez has assembled a number of important contributors to the research area and grouped the 15 chapters into six parts. … many MDs, biologists, and pharmacologists will find the book … appealing, as the receptor class is involved in numerous cardiovascular and pulmonary diseases." (Boris Schmidt, ChemMedChem, Issue 1, 2006)

Editors and Affiliations

  • Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland

    Dianne M. Perez

Bibliographic Information

  • Book Title: The Adrenergic Receptors

  • Book Subtitle: In the 21st Century

  • Editors: Dianne M. Perez

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1385/1592599311

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2006

  • Hardcover ISBN: 978-1-58829-423-4Published: 01 September 2005

  • Softcover ISBN: 978-1-61737-559-0Published: 09 November 2010

  • eBook ISBN: 978-1-59259-931-8Published: 28 October 2007

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: XII, 404

  • Topics: Pharmacy

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