The Adrenergic Receptors

1. Front Matter

   Pages i-xi

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2. Historical Perspectives

   1. Front Matter

      Pages 1-1

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   2. Adrenergic Receptors

      • David B. Bylund

      Pages 3-21

3. Structure-Function

   1. Front Matter

      Pages 23-23

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   2. Ligand Binding, Activation, and Agonist Trafficking

      • Angela M. Finch, Valerie Sarramegna, Robert M. Graham

      Pages 25-85

   3. New Signal Transduction Paradigms

      • Kenneth P. Minneman

      Pages 87-106

   4. Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors

      • Michael T. Piascik, Mary Lolis García-Cazarin, Steven R. Post

      Pages 107-128

   5. Adrenergic Receptors in Clinical Medicine

      • Martin C. Michel, Paul A. Insel

      Pages 129-147

4. Imaging Adrenergic Receptors and Their Function

   1. Front Matter

      Pages 149-149

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   2. Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors

      • John C. McGrath, Craig J. Daly

      Pages 151-172

   3. Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors

      • Dianne M. Perez

      Pages 173-204

5. Genetically Altered Mouse Models

   1. Front Matter

      Pages 205-205

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   2. The α1-Adrenergic Receptors

      • Paul C. Simpson

      Pages 207-240

   3. The α2-Adrenergic Receptors

      • Christopher M. Tan, Lee E. Limbird

      Pages 241-265

   4. The β-Adrenergic Receptors

      • Yang Xiang, Brian Kobilka

      Pages 267-291

   5. Lessons From Overexpressed Mouse Models

      • Cinzia Perrino, Liza Barki-Harrington, Howard A. Rockman

      Pages 293-320

   6. Adrenergic Receptor Signaling Components in Gene Therapy

      • Andrea D. Eckhart, Walter J. Koch

      Pages 321-335

6. Pharmacogenomics

   1. Front Matter

      Pages 337-337

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   2. Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms

      • Stephen B. Liggett

      Pages 339-364

   3. Microarray Analysis of Novel Adrenergic Receptor Functions

      • Boyd Rorabaugh, June Yun, Dianne M. Perez

      Pages 365-391

An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.

• blood
• blood pressure
• gene
• gene therapy
• genomics
• imaging
• medicine
• microarray
• mouse
• outcome
• receptor signaling
• regulation
• research
• signal transduction
• therapy

From the reviews:

"...useful to anyone interested in adrenoceptor physiology/pharmacology or in the design of drugs interacting with the receptor or its signal transduction pathway." -Journal of Medicinal Chemistry

"Dianne Perez has assembled a number of important contributors to the research area and grouped the 15 chapters into six parts. … many MDs, biologists, and pharmacologists will find the book … appealing, as the receptor class is involved in numerous cardiovascular and pulmonary diseases." (Boris Schmidt, ChemMedChem, Issue 1, 2006)

• Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland

  Dianne M. Perez

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