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Cancer Gene Therapy

  • Book
  • © 2005

Overview

Editors:
  1. David T. Curiel

    1. Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham
      Division of Human Gene Therapy, Department of Pathology, University of Alabama at Birmingham, Birmingham
      Division of Human Gene Therapy, Department of Surgery, University of Alabama at Birmingham, Birmingham
      Division of Human Gene Therapy, Department of Gene Therapy Center, University of Alabama at Birmingham, Birmingham

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  2. Joanne T. Douglas

    1. Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham
      Division of Human Gene Therapy, Department of Pathology, University of Alabama at Birmingham, Birmingham
      Division of Human Gene Therapy, Department of Surgery, University of Alabama at Birmingham, Birmingham
      Division of Human Gene Therapy, Department of Gene Therapy Center, University of Alabama at Birmingham, Birmingham

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Cancer Research (CCR)

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-xii
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  2. Cancer Gene Therapy

    • Malcolm K. Brenner
    Pages 1-8

  3. The Genetic Basis of Cancer

    • Akseli Hemminki, Kari Hemminki
    Pages 9-18

  4. Tumor Suppressor Gene Replacement for Cancer

    • Jack A. Roth, Susan F. Grammer
    Pages 19-33

  5. Antisense Technology

    • Ruiwen Zhang, Hui Wang
    Pages 35-49

  6. Cancer Therapeutic Applications of Ribozymes and RNAi

    • Lisa Scherer, John J. Rossi
    Pages 51-63

  7. Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy

    • Andrew Bateman, Vy Phan, Alan Melcher, Emmanouela Linardakis, Kevin Harrington, Richard Vile
    Pages 65-80

  8. Suicide Gene Therapy

    • Caroline J. Springer, Ion Niculescu-Duvaz
    Pages 81-107

  9. Molecular Chemotherapy Approaches

    • Daniel H. Palmer, David J. Kerr
    Pages 109-128

  10. Genetic Immunotherapy Approaches

    • Denise R. Shaw, Albert F. LoBuglio
    Pages 129-141

  11. Immunotherapy of Cancer by Dendritic Cell-Targeted Gene Transfer

    • Tanja D. de Gruijl, Herbert M. Pinedo, Rik J. Scheper
    Pages 143-172

  12. Dendritic Cells

    • Weiping Zou, Shuang Wei, Tyler J. Curiel
    Pages 173-184

  13. Polynucleotide Immunization for Cancer Therapy

    • Theresa V. Strong
    Pages 185-197

  14. Development of Oncolytic Replication-Competent Herpes Simplex Virus Vectors

    • Tomoki Todo, Samuel D. Rabkin
    Pages 199-210

  15. Development of Oncolytic Adenoviruses

    • John A. Howe, Robert Ralston, Murali Ramachandra
    Pages 211-233

  16. Conditionally Replicating Adenoviruses for Cancer Treatment

    • Ramon Alemany
    Pages 235-248

  17. Reovirus as an Oncolytic Agent

    • Megan K. Patrick, Kara L. Norman, Patrick W. K. Lee
    Pages 249-260

  18. Antiangiogenic Gene Therapy of Cancer

    • Steve Gyorffy, Jack Gauldie, A. Keith Stewart, Xiao-Yan Wen
    Pages 261-271

  19. Proapoptotic Strategy in Cancer Gene Therapy

    • David H. Holman, Marc L. Hyer, Ahmed El-Zawahry, Gina M. Keller, James S. Norris
    Pages 273-286

  20. Antimetastasis

    • Duen-Hwa Yan, Kung-Ming Rau, Mien-Chie Hung
    Pages 287-298
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Keywords

About this book

A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Reviews

"...represents an outstanding work, which should not be missed in all laboratories dealing with cancer gene therapy." - Neoplasma

Editors and Affiliations

  • Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham

    David T. Curiel, Joanne T. Douglas

  • Division of Human Gene Therapy, Department of Pathology, University of Alabama at Birmingham, Birmingham

    David T. Curiel, Joanne T. Douglas

  • Division of Human Gene Therapy, Department of Surgery, University of Alabama at Birmingham, Birmingham

    David T. Curiel, Joanne T. Douglas

  • Division of Human Gene Therapy, Department of Gene Therapy Center, University of Alabama at Birmingham, Birmingham

    David T. Curiel, Joanne T. Douglas

Bibliographic Information

  • Book Title: Cancer Gene Therapy

  • Editors: David T. Curiel, Joanne T. Douglas

  • Series Title: Contemporary Cancer Research

  • DOI: https://doi.org/10.1007/978-1-59259-785-7

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2005

  • Hardcover ISBN: 978-1-58829-213-1Published: 03 September 2004

  • Softcover ISBN: 978-1-61737-425-8Published: 09 November 2010

  • eBook ISBN: 978-1-59259-785-7Published: 03 November 2007

  • Edition Number: 1

  • Number of Pages: XII, 490

  • Topics: Cancer Research

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