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Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

  • Book
  • © 2004

Overview

Editors:
  1. William D. Figg

    1. Center for Cancer Research, National Cancer Institute, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Howard L. McLeod

    1. Washington University School of Medicine, St. Louis, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Molecular Targets

    • Udai Banerji, Ian Judson, Paul Workman
    Pages 1-27

  3. Preclinical Screening for New Anticancer Agents

    • Angelika M. Burger, Heinz-Herbert Fiebig
    Pages 29-44

  4. Mouse Models in Cancer Drug Discovery and Development

    • Edward A. Sausville, Melinda Hollingshead
    Pages 45-55

  5. Defining the Starting Dose

    • Howard Gurney
    Pages 57-73

  6. Phase I Trials in Oncology

    • James Cassidy
    Pages 75-80

  7. Analytical Methods

    • Hans Ehrsson, Staffan Eksborg, Jonas Bergh
    Pages 81-90

  8. Validation and Control of Bioanalytical Methods in Clinical Drug Development

    • H. Thomas Karnes
    Pages 91-110

  9. Clinical Pharmacology Overview

    • Andrew P. Beelen, Lionel D. Lewis
    Pages 111-127

  10. Pharmacokinetic Modeling

    • Sharyn D. Baker, Michelle A. Rudek
    Pages 129-137

  11. Pharmacodynamic Modeling

    • Kenneth S. Bauer, William P. Petros
    Pages 139-148

  12. Pharmacometric Knowledge-Based Oncology Drug Development

    • Paul J. Williams, James A. Uchizono, Ene I. Ette
    Pages 149-167

  13. Protein Binding of Anticancer Drugs

    • Alex Sparreboom, Walter J. Loos
    Pages 169-188

  14. Metabolism (Non-CYP Enzymes)

    • Sally A. Coulthard, Alan V. Boddy
    Pages 189-213

  15. Cytochrome P450 and Anticancer Drugs

    • Yuichi Ando
    Pages 215-229

  16. Polymorphisms in Genes of Drug Targets and Metabolism and in DNA Repair

    • Jan Stoehlmacher, Syma Iqbal, Heinz-Josef Lenz
    Pages 231-243

  17. Drug Interactions

    • Laurent P. Rivory
    Pages 245-266

  18. ABC Transporters

    • Susan E. Bates, Tito Fojo
    Pages 267-288

  19. Intrathecal Chemotherapy

    • Jeff Stone, Susan M. Blaney
    Pages 289-306

  20. Use of Microdialysis in Preclinical and Clinical Development of Anticancer Agents

    • William C. Zamboni
    Pages 307-326
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Keywords

About this book

Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.

Reviews

"...an invaluable overview of the experimental and clinical processes that lead to anticancer drugs, creating a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials." - Tumori

Editors and Affiliations

  • Center for Cancer Research, National Cancer Institute, Bethesda, USA

    William D. Figg

  • Washington University School of Medicine, St. Louis, USA

    Howard L. McLeod

Bibliographic Information

  • Book Title: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

  • Editors: William D. Figg, Howard L. McLeod

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-734-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Humana Press 2004

  • eBook ISBN: 978-1-59259-734-5Published: 26 March 2004

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XV, 623

  • Topics: Pharmacy

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