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Systems Genetics

Methods and Protocols

  • Book
  • © 2017

Overview

Editors:
  1. Klaus Schughart

    1. Department of Infection Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine Hannover, Braunschweig, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Robert W. Williams

    1. Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1488)

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Table of contents (29 protocols)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Resources for Systems Genetics

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Resources for Systems Genetics

      • Robert W. Williams, Evan G. Williams
      Pages 3-29

    3. Heterogeneous Stock Populations for Analysis of Complex Traits

      • Leah C. Solberg Woods, Richard Mott
      Pages 31-44

  3. Tools for Analysis and Integration in Systems Genetics

    1. Front Matter

      Pages 45-45
      Download chapter PDF

    2. Mouse Genome Informatics (MGI): Resources for Mining Mouse Genetic, Genomic, and Biological Data in Support of Primary and Translational Research

      • Janan T. Eppig, Cynthia L. Smith, Judith A. Blake, Martin Ringwald, James A. Kadin, Joel E. Richardson et al.
      Pages 47-73

    3. GeneNetwork: A Toolbox for Systems Genetics

      • Megan K. Mulligan, Khyobeni Mozhui, Pjotr Prins, Robert W. Williams
      Pages 75-120

    4. Complex Trait Analyses of the Collaborative Cross: Tools and Databases

      • Ramesh Ram, Grant Morahan
      Pages 121-129

    5. Integrative Functional Genomics for Systems Genetics in GeneWeaver.org

      • Jason A. Bubier, Michael A. Langston, Erich J. Baker, Elissa J. Chesler
      Pages 131-152

    6. A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel

      • Christoph D. Rau, Mete Civelek, Calvin Pan, Aldons J. Lusis
      Pages 153-188

    7. Expression QTLs Mapping and Analysis: A Bayesian Perspective

      • Martha Imprialou, Enrico Petretto, Leonardo Bottolo
      Pages 189-215

    8. Epigenetics and Control of RNAs

      • Henrike Maatz, Sebastiaan van Heesch, Franziska Kreuchwig, Allison Faber, Eleonora Adami, Norbert Hubner et al.
      Pages 217-237

    9. Integrating Multidimensional Data Sources to Identify Genes Regulating Complex Phenotypes

      • Rupert W. Overall
      Pages 239-250

    10. RNA-Seq in the Collaborative Cross

      • Richard Green, Courtney Wilkins, Martin T. Ferris, Michael Gale Jr.
      Pages 251-263

    11. QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment

      • Dan Gatti, John E. French, Klaus Schughart
      Pages 265-281

    12. Visualization of Results from Systems Genetics Studies in Chromosomal Context

      • Karen Y. Oróstica, Ricardo A. Verdugo
      Pages 283-297

    13. Using Baseline Transcriptional Connectomes in Rat to Identify Genetic Pathways Associated with Predisposition to Complex Traits

      • Laura Saba, Paula Hoffman, Boris Tabakoff
      Pages 299-317

    14. Precise Network Modeling of Systems Genetics Data Using the Bayesian Network Webserver

      • Jesse D. Ziebarth, Yan Cui
      Pages 319-335

    15. Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease

      • Aida Moreno-Moral, Francesco Pesce, Jacques Behmoaras, Enrico Petretto
      Pages 337-362

  4. Systems Genetics Use Cases: Mapping and Combining Multiple Phenotypic Traits

    1. Front Matter

      Pages 363-363
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Keywords

About this book

This volume focuses on the use of system genetic methods and the use of murine models to study the role of gene variants and environmental factors on human health and disease—what is now often called personalized or precision health care. The protocols in this book will help readers analyze genetic causes of heritable variation across a wide range of systems and traits using rodent models. The chapters in this book are separated into three sections that cover: 1) resources for systems genetics; 2) tools for analysis and integration in systems genetics; and 3) systems genetics use cases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and tools, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and thorough, Systems Genetics: Methods and Protocols is a valuable resource for anyone who is interested in this diverse field.

Editors and Affiliations

  • Department of Infection Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine Hannover, Braunschweig, Germany

    Klaus Schughart

  • Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, USA

    Robert W. Williams

Bibliographic Information

  • Book Title: Systems Genetics

  • Book Subtitle: Methods and Protocols

  • Editors: Klaus Schughart, Robert W. Williams

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-6427-7

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2017

  • Hardcover ISBN: 978-1-4939-6425-3Published: 08 December 2016

  • Softcover ISBN: 978-1-4939-8196-0Published: 06 July 2018

  • eBook ISBN: 978-1-4939-6427-7Published: 08 December 2016

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIV, 609

  • Number of Illustrations: 27 b/w illustrations, 137 illustrations in colour

  • Topics: Human Genetics

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