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Systems Medicine

  • Book
  • © 2016

Overview

Editors:
  1. Ulf Schmitz

    1. Dept of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Olaf Wolkenhauer

    1. Dept of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1386)

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Table of contents (19 protocols)

  1. Front Matter

    Pages i-xiv
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  2. A Road Map Toward Systems Medicine

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Systems Medicine: Sketching the Landscape

      • Marc Kirschner
      Pages 3-15

    3. Taking Bioinformatics to Systems Medicine

      • Antoine H. C. van Kampen, Perry D. Moerland
      Pages 17-41

    4. Systems Medicine: The Future of Medical Genomics, Healthcare, and Wellness

      • Mansoor Saqi, Johann Pellet, Irina Roznovat, Alexander Mazein, Stéphane Ballereau, Bertrand De Meulder et al.
      Pages 43-60

    5. Next-Generation Pathology

      • Peter D. Caie, David J. Harrison
      Pages 61-72

    6. Training in Systems Approaches for the Next Generation of Life Scientists and Medical Doctors

      • Damjana Rozman, Jure Acimovic, Bernd Schmeck
      Pages 73-86

    7. Systems Medicine in Pharmaceutical Research and Development

      • Lars Kuepfer, Andreas Schuppert
      Pages 87-104

  3. Opinions and Persepectives

    1. Front Matter

      Pages 105-105
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    2. Systems Medicine and Infection

      • Ruth Bowness
      Pages 107-118

    3. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy

      • Bernd Schmeck, Wilhelm Bertrams, Xin Lai, Julio Vera
      Pages 119-133

    4. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive

      • Martin Eberhardt, Xin Lai, Namrata Tomar, Shailendra Gupta, Bernd Schmeck, Alexander Steinkasserer et al.
      Pages 135-179

    5. Systems Medicine in Oncology: Signaling Network Modeling and New-Generation Decision-Support Systems

      • Silvio Parodi, Giuseppe Riccardi, Nicoletta Castagnino, Lorenzo Tortolina, Massimo Maffei, Gabriele Zoppoli et al.
      Pages 181-219

    6. Neurological Diseases from a Systems Medicine Point of View

      • Marek Ostaszewski, Alexander Skupin, Rudi Balling
      Pages 221-250

  4. Systems Medicine Projects and Case Studies

    1. Front Matter

      Pages 251-251
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    2. Computational Modeling of Human Metabolism and Its Application to Systems Biomedicine

      • Maike K. Aurich, Ines Thiele
      Pages 253-281

    3. From Systems Understanding to Personalized Medicine: Lessons and Recommendations Based on a Multidisciplinary and Translational Analysis of COPD

      • Josep Roca, Isaac Cano, David Gomez-Cabrero, Jesper Tegnér
      Pages 283-303

    4. RNA Systems Biology for Cancer: From Diagnosis to Therapy

      • Raheleh Amirkhah, Ali Farazmand, Olaf Wolkenhauer, Ulf Schmitz
      Pages 305-330

    5. Mathematical Models of Pluripotent Stem Cells: At the Dawn of Predictive Regenerative Medicine

      • Pınar Pir, Nicolas Le Novère
      Pages 331-350

  5. Tools and Methodologies

    1. Front Matter

      Pages 351-351
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Keywords

About this book

This volume guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach. Chapters provide an outlook on the role that systems medicine may or should play in various medical fields, and describe different facets of the systems medicine approach in action. Ultimately it introduces tools, resources and methodologies from bioinformatics and systems biology, and how to apply these in a systems medicine project. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, and discuss experimental and computational approaches, methods, and tools that should be considered for a successful systems medicine project. Systems Medicine aims to motivate and provide guidance for collaborations across disciplines to tackle today's challenges related to human healthand well-being.

Editors and Affiliations

  • Dept of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany

    Ulf Schmitz, Olaf Wolkenhauer

Bibliographic Information

  • Book Title: Systems Medicine

  • Editors: Ulf Schmitz, Olaf Wolkenhauer

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-3283-2

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3282-5Published: 17 December 2015

  • Softcover ISBN: 978-1-4939-8011-6Published: 29 March 2019

  • eBook ISBN: 978-1-4939-3283-2Published: 16 December 2015

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIV, 478

  • Number of Illustrations: 7 b/w illustrations, 61 illustrations in colour

  • Topics: Bioinformatics, Systems Biology

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