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Bone Drugs in Pediatrics

Efficacy and Challenges

  • Book
  • © 2014

Overview

Editors:
  1. Gordon L. Klein

    1. Department of Orthopaedic Surgery, University of Texas Medical Branch, Galveston, USA

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  • Presents evidence for the use of certain drugs in the treatment and prevention of bone loss in children

  • Balances the pros and cons of utilizing these drugs in the pediatric population

  • Highlights the potential for future use of these and other drugs with children

  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Introduction

    • Gordon L. Klein
    Pages 1-3

  3. Developmental Pharmacokinetics: Drug Disposition Relative to Age

    • Michael D. Reed, Michelle L. Bestic
    Pages 5-22

  4. Drug Development for Pediatric Diseases with Bone Loss

    • Chi Zhang
    Pages 23-36

  5. Paediatric Bone Physiology and Monitoring the Safety and Efficacy of Bone Drugs in Children

    • John G. Logan, J. H. Duncan Bassett, Moira S. Cheung
    Pages 37-65

  6. Bisphosphonates in Osteogenesis Imperfecta

    • Andrew Biggin, Craig F. Munns
    Pages 67-80

  7. Use of Bisphosphonates in Genetic Diseases Other than Osteogenesis Imperfecta

    • Maria Luisa Bianchi
    Pages 81-99

  8. Bisphosphonates in Pediatric Burn Injury

    • Gordon L. Klein
    Pages 101-115

  9. Growth Hormone and Bone

    • Daisuke Harada, Yoshiki Seino
    Pages 117-134

  10. Growth Hormone and Oxandrolone in Burned Children

    • Nigel Tapiwa Mabvuure, Alexis N. Thomas, Linda E. Sousse
    Pages 135-152

  11. Pediatric Bone Drugs: Calcium and Vitamin D

    • Melissa S. Putman, Catherine M. Gordon
    Pages 153-181

  12. Pediatric Maxillofacial Conditions and Drugs

    • Srinivas M. Susarla, Christina M. Jacobsen, Shelly Abramowicz
    Pages 183-198

  13. Newer Adult Bone Drugs

    • Natalie E. Cusano, Aline G. Costa, Barbara C. Silva, John P. Bilezekian
    Pages 199-221

  14. Conclusion: Whither (or Wither?) the Pharmacology of Pediatric Bone?

    • Gordon L. Klein
    Pages 223-224

  15. Back Matter

    Pages 225-233
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Keywords

About this book

Bone Drugs in Pediatrics brings together in one place the evidence for the use of certain drugs in the treatment and prevention of bone loss in children, as well as the reservations still present in the pediatric community regarding their use. Beginning with a discussion of developmental pharmacokinetics and drug development for pediatric diseases where bone loss occurs, such as osteogenesis imperfecta, the physiology of pediatric bone and how best to monitor the safety and efficacy of these drugs is presented. The pros and cons of utilizing the drugs themselves – such as bisphosphonates, antiresorptives and anabolic agents – within the pediatric population are carefully considered, with an eye toward safe and effective integration. The potential use of drugs in future treatment is also highlighted. On the whole, Bone Drugs in Pediatrics is a cogent presentation of the ongoing debate surrounding the potential for pharmacological interventions in pediatric bone loss.

Editors and Affiliations

  • Department of Orthopaedic Surgery, University of Texas Medical Branch, Galveston, USA

    Gordon L. Klein

About the editor

Gordon L. Klein, MD, MPH, Department of Orthopaedic Surgery, University of Texas Medical Branch, Galveston, TX, USA.

Bibliographic Information

  • Book Title: Bone Drugs in Pediatrics

  • Book Subtitle: Efficacy and Challenges

  • Editors: Gordon L. Klein

  • DOI: https://doi.org/10.1007/978-1-4899-7436-5

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4899-7435-8Published: 03 April 2014

  • Softcover ISBN: 978-1-4899-7848-6Published: 23 August 2016

  • eBook ISBN: 978-1-4899-7436-5Published: 02 April 2014

  • Edition Number: 1

  • Number of Pages: XIII, 233

  • Number of Illustrations: 17 b/w illustrations, 28 illustrations in colour

  • Topics: Endocrinology, Orthopedics, Pediatrics

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