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Biology and Physiology of the Blood-Brain Barrier

Transport, Cellular Interactions, and Brain Pathologies

  • Book
  • © 1996

Overview

Editors:
  1. Pierre-Olivier Couraud

    1. Institut Cochin de Génétique Moléculaire, Paris, France

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  2. Daniel Scherman

    1. CNRS-Rhône-Poulenc Rorer, Vitry sur Seine, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Behavioral Biology (ABBI, volume 46)

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Table of contents (63 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  3. Physiological Transports through the Blood-Brain Barrier

    1. Blood-Brain Barrier Taurine Transport and Brain Volume Regulation

      • Richard F. Keep, Walter Stummer, Jianming Xiang, A. Lorris Betz
      Pages 11-16

    2. Volume Regulation of the in Vitro Blood-Brain Barrier by Osmoreactive Amino Acids during Stress

      • P. J. Gaillard, A. G. De Boer, D. D. Breimer
      Pages 17-19

    3. A Reduction in the Transfer of Amino Acids Across the Blood-Brain Barrier Might Not be the Sole Mechanism by Which Vasopressin Affects Amino Acid Levels within the Brain

      • A. Reichel, D. J. Begley, A. Ermisch
      Pages 21-26

    4. Differential Amino Acid Uptake into Cerebral Parenchyma and Capillary Cells during Development

      • Hameed Al-Sarraf, Kevin A. Smart, Malcolm B. Segal, Jane E. Preston
      Pages 27-33

    5. Transport of 3H L-Alanine Across the Blood-Brain Barrier of in Situ Perfused Guinea Pig Brain

      • Ivanka D. Markovic, Zoran B. Redzic, Suzana S. Jovanovic, Dusan M. Mitrovic, Ljubisa M. Rakic
      Pages 35-39

    6. Distribution of Small Neutral Amino Acids after Penetrating the Luminal Side of the Guinea Pig Blood-Brain Barrier

      • S. S. Jovanovic, Z. B. Redzic, I. D. Markovic, D. M. Mitrovic, Lj. M. Rakic
      Pages 41-45

    7. The Blood-Brain Barrier, Potassium, and Brain Growth

      • Richard F. Keep, Jianming Xiang, A. Lorris Betz
      Pages 47-50

    8. Receptor-Mediated Transcytosis of Transferrin through Blood-Brain Barrier Endothelial Cells

      • Laurence Descamps, Marie-Pierre Dehouck, Gérard Torpier, Roméo Cecchelli
      Pages 51-54

    9. Intracerebral Expression of Transferrin Receptors in Iron-Deficient Rats

      • T. Moos, T. M. Hansen
      Pages 55-61

    10. Vascular Permeability to Hemorphins in the Central Nervous System

      • H. S. Sharma, K. Sanderson, E.-L. Glämsta, Y. Olsson, F. Nyberg
      Pages 63-68

    11. The Effect of Glycosylation on the Uptake of an Enkephalin Analogue into the Central Nervous System

      • Sarah A. Williams, Thomas J. Abbruscato, Lajos Szabo, Robin Polt, Victor Hruby, Thomas P. Davis
      Pages 69-77

    12. Blood-Retina Barrier Properties of the Pecten Oculi of the Chicken

      • Holger Gerhardt, Stefan Liebner, Hartwig Wolburg
      Pages 79-81

  4. Blood-Brain Barrier and Drug Delivery to the Brain

    1. The Microarchitecture of Cerebral Vessels

      • Kenneth R. Davies, Grace Richardson, Wendy Akmentin, Virgil Acuff, Joseph D. Fenstermacher
      Pages 83-91

    2. Development of Blood-Brain Barrier Tight Junctions

      • Uwe Kniesel, Werner Risau, Hartwig Wolburg
      Pages 93-95

    3. Membrane Fractionation of Brain Capillary Endothelial Cells and Analysis of Lipid Polarity

      • Bernhard J. Tewes, Hans-Joachim Galla
      Pages 97-101

    4. “Brain-Tissue-Specific” Versus “Serum-Specific” Posttranslational Modification of Human Cerebrospinal Fluid Polypeptides with N-Linked Carbohydrates

      • Andrea Hoffmann, Eckart Grabenhorst, Manfred Nimtz, Harald S. Conradt
      Pages 103-107

    5. Blood-Brain Barrier Properties in Vitro as Related to the Neurotransmitter Serotonin

      • P. Brust, S. Matys, J. Wober, A. Friedrich, R. Bergmann, B. Ahlemeyer
      Pages 109-115
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Keywords

About this book

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho­ logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu­ dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.

Editors and Affiliations

  • Institut Cochin de Génétique Moléculaire, Paris, France

    Pierre-Olivier Couraud

  • CNRS-Rhône-Poulenc Rorer, Vitry sur Seine, France

    Daniel Scherman

Bibliographic Information

  • Book Title: Biology and Physiology of the Blood-Brain Barrier

  • Book Subtitle: Transport, Cellular Interactions, and Brain Pathologies

  • Editors: Pierre-Olivier Couraud, Daniel Scherman

  • Series Title: Advances in Behavioral Biology

  • DOI: https://doi.org/10.1007/978-1-4757-9489-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1996

  • Hardcover ISBN: 978-0-306-45362-5Published: 31 December 1996

  • Softcover ISBN: 978-1-4757-9491-5Published: 08 May 2013

  • eBook ISBN: 978-1-4757-9489-2Published: 29 June 2013

  • Series ISSN: 0099-6246

  • Edition Number: 1

  • Number of Pages: XVI, 388

  • Topics: Neurology, Neurosurgery, Pathology, Animal Anatomy / Morphology / Histology, Plant Sciences, Animal Physiology

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