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  • © 1983

The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents

Editors:

  1. Amleto Castellani

    1. Casaccia Center for Nuclear Studies, Rome, Italy

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Table of contents (49 chapters)

  1. Front Matter

    Pages i-xi
    PDF

  2. Lectures

    7. Mutagen-Induced Chromosome Damage in Man

      • Paul E. Perry
      Pages 77-90

    9. Repair and Expression of Aflatoxin B1-Induced DNA Damage

      • Steven A. Leadon, Paul A. Amstad, Peter A. Cerutti
      Pages 105-117

    14. Effects of Various Promoters on Cell Transformation by Simian Virus 40 Mutants

      • L. Daya-Grosjean, R. Monier, A. Sarasin
      Pages 179-195
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About this book

In this volume are collected 30 papers, 9 round table discus­ sions and 11 communications presented at the ASI Course on "The use of human cells for the evaluation of risk from physical and chemical agents", sponsored by NATO and organized by ENEA. The aim of the Course was to present different scientific ap­ proaches and technical advices in order to get dose-effect relation­ ships which are the basis for risk evaluation. The scientific back­ ground which is behind this approach was extensively discussed. Emphasis has been given to the use of human cells or human data in order to attempt to have a correct and realistic evaluation of the damage in humans. There are many criticisms on the use of animal data for human risk evaluation because of differences between species and between strains within the same species: differences in metabolism, activa­ tion processes and DNA repair ability makes uncertain the extrapola­ tion of animal data to humans. Also data obtained using specific strains or highly inbred strains in order to reduce the variance are not applicable due to the heterogeneity of the human population connected with individual responses. In this respect only the use of human cells enable us to detect the individual variability and to identify sensitive subpopu­ lations that would be at greater risk. My appreciation to Pieranita and Alberto Castellani for the as­ sistance during the meeting and to Giuseppe Biondi for his help in some of the editorial work.
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Keywords

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Editors and Affiliations

  • Casaccia Center for Nuclear Studies, Rome, Italy

    Amleto Castellani

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Bibliographic Information

  • Book Title: The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents

  • Editors: Amleto Castellani

  • DOI: https://doi.org/10.1007/978-1-4757-1117-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1983

  • Softcover ISBN: 978-1-4757-1119-6Published: 15 April 2013

  • eBook ISBN: 978-1-4757-1117-2Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: XI, 809

  • Number of Illustrations: 132 b/w illustrations

  • Topics: Veterinary Medicine/Veterinary Science

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Buy it now

eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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