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Table of contents (49 chapters)
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Front Matter
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Lectures
Keywords
About this book
In this volume are collected 30 papers, 9 round table discus sions and 11 communications presented at the ASI Course on "The use of human cells for the evaluation of risk from physical and chemical agents", sponsored by NATO and organized by ENEA. The aim of the Course was to present different scientific ap proaches and technical advices in order to get dose-effect relation ships which are the basis for risk evaluation. The scientific back ground which is behind this approach was extensively discussed. Emphasis has been given to the use of human cells or human data in order to attempt to have a correct and realistic evaluation of the damage in humans. There are many criticisms on the use of animal data for human risk evaluation because of differences between species and between strains within the same species: differences in metabolism, activa tion processes and DNA repair ability makes uncertain the extrapola tion of animal data to humans. Also data obtained using specific strains or highly inbred strains in order to reduce the variance are not applicable due to the heterogeneity of the human population connected with individual responses. In this respect only the use of human cells enable us to detect the individual variability and to identify sensitive subpopu lations that would be at greater risk. My appreciation to Pieranita and Alberto Castellani for the as sistance during the meeting and to Giuseppe Biondi for his help in some of the editorial work.
Editors and Affiliations
Bibliographic Information
Book Title: The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents
Editors: Amleto Castellani
DOI: https://doi.org/10.1007/978-1-4757-1117-2
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 1983
Softcover ISBN: 978-1-4757-1119-6Published: 15 April 2013
eBook ISBN: 978-1-4757-1117-2Published: 29 June 2013
Edition Number: 1
Number of Pages: XI, 809
Number of Illustrations: 132 b/w illustrations