Myoblast Transfer Therapy

1. Front Matter

   Pages i-xii

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2. Molecular Biology of Myogenesis and Regeneration

   1. Front Matter

      Pages 1-1

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   2. MyoD: A Regulatory Gene of Skeletal Myogenesis

      • Stephen J. Tapscott, Robert L. Davis, Andrew B. Lassar, Harold Weintraub

      Pages 3-6

   3. Myoblasts, Satellite Cells, and Myoblast Transfer

      • Frank E. Stockdale, E. Janet Hager, Susan E. Fernyak, Joseph X. DiMario

      Pages 7-11

   4. Regeneration of Skeletal Muscle Fibers after Necrosis

      • Stirling Carpenter

      Pages 13-15

   5. Detection of Truncated Dystrophin in Fetal DMD Myotubes

      • Ieke B. Ginjaar, Egbert Bakker, Johan T. den Dunnen, Andy Wessels, Marleen M. B. van Paassen, Maarten D. Kloosterman et al.

      Pages 17-23

3. Myoblast/Satellite Cell Antigenicity

   1. Front Matter

      Pages 29-29

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   2. Immunological Aspects of Histoincompatible Myoblast Transfer into Non-Tolerant Hosts

      • George Karpati

      Pages 31-34

   3. A Comparison of Long-Term Survival of Muscle Precursor Cell Suspensions and Minced Muscle Allografts in the Non-Tolerant Mouse

      • Diana J. Watt

      Pages 35-39

   4. N-CAM is a Target Cell Surface Antigen for the Purification of Muscle Cells for Myoblast Transfer Therapy

      • Frank S. Walsh

      Pages 41-46

   5. Immunochemical Analyses of the Myoblast Membrane and Lineage

      • Stephen J. Kaufman

      Pages 47-55

4. Practical Aspects of Myoblast Implantation

   1. Front Matter

      Pages 67-67

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   2. The Principles and Practice of Myoblast Transfer

      • George Karpati

      Pages 69-74

   3. Myoblast Transfer Improves Muscle Genetics/Structure/Function and Normalizes the Behavior and Life-Span of Dystrophic Mice

      • Peter K. Law, Tena G. Goodwin, H.-J. Li, Ghaith Ajamoughli, Ming Chen

      Pages 75-87

   4. Practical Aspects of Myoblast Implantation: Investigations on Two Inherited Myopathies in Animals

      • Jennifer E. Morgan

      Pages 89-96

   5. Purification and Proliferation of Human Myoblasts Isolated with Fluorescence Activated Cell Sorting

      • Helen M. Blau, Cecelia Webster, Grace K. Pavlath

      Pages 97-100

   6. The Proliferation and Fusion of Myoblasts In Vivo

      • Miranda D. Grounds

      Pages 101-106

   7. The DMD Gene Promoter: A Potential Role in Gene Therapy

      • Peter N. Ray, Henry J. Klamut, Ronald G. Worton

      Pages 107-112

5. In Situ Fusion: Nuclear Domains and mRNA/Protein Migration

   1. Front Matter

      Pages 129-129

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   2. Fibroblasts Fuse with Myotubes Developing in Culture

      • Nirupa Chaudhari, Kurt G. Beam

      Pages 131-137

I am pleased to introduce this volume on Myoblast Transfer Therapy on behalf of the Muscular Dystrophy Association and all of its Advisory Committees. The international conference which led to this volume brought together leading basic scientists and clinical investigators for the purpose of coordinating the development of this new field in the fight against muscular dystrophy. The Muscular Dystrophy Association is the nation's most rapidly growing voluntary health agency in terms of its programs of patient care, research, and professional and public education. Success is attributable to its National Chairman, Jerry Lewis, to its effective corporate membership, and to the many physicians and scientists who give their time freely to advise on policies, to review grant applications, and to participate in meetings such as this. I should like to acknowledge a large number of other individuals to whom we are indebted: the broad segment of the American public which continually and generously supports our spectrum of services. The Muscular Dystrophy Association, next year, should raise in excess of $115,000,000. These contributions are derived from more than 10 million American families. These families are not only pledging their money but expressing their hopes that we will find answers to the tragic problem of neuromuscular disease. We are confident that the fruits of this meeting will move the frontier of research forward toward that goal.

• Promoter
• Termination
• gene therapy
• genes
• genetics
• molecular biology
• myogenesis

• University of Rochester, Rochester, USA

  Robert C. Griggs

• McGill University, Montreal, Canada

  George Karpati

Policies and ethics