Kinins V

1. Front Matter

   Pages i-xxvi

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2. Tissue Kallikreins and Kinins: Roles in Human Disease and Target for New Drug Development

   1. Tissue Kallikreins and Kinins: Roles in Human Disease and Target for New Drug Development

      • Harry S. Margolius

      Pages 1-6

3. Control of Kininogen Gene Expression

   1. Control of Kininogen Gene Expression

      • S. Nakanishi, N. Kitamura, H. Ohkubo, A. Kakizuka, R. Kageyama, Y. Masu et al.

      Pages 7-18

4. Angiotensin I Converting Enzyme Inhibitors, Kinin and Prostaglandin Systems

   1. Biochemistry of Renin

      • Tatsuo Kokubu, Kunio Hiwada, Eiki Murakami, Shinjiro Muneta

      Pages 19-24

   2. Angiotensin I Converting Enzyme

      • Randal A. Skidgel, Ervin G. Erdös

      Pages 25-28

   3. Pharmacokinetics of Angiotensin Converting Enzyme Inhibitors in Plasma and Tissue Using Radioinhibitor Binding and Displacement Assays

      • C. I. Johnston, B. Jackson, R. Cubela, D. Sivell, M. Kozhuki

      Pages 29-34

   4. Role of the Endogenous Angiotensin II in the Antihypertensive Effect of MK 421 in Rats made Hypertensive by Norepinephrine or Vasopressin

      • Minoru Yasujima, Keishi Abe, Masaya Tanno, Kaoru Yoshinaga

      Pages 35-38

   5. Significance of Kallikrein-Kinin and Renin-Angiotensin Systems in the Hypotensive Mechanism of Angiotensin-I Converting Enzyme Inhibitors in Essential Hypertensives

      • Osamu Iimura, Kazuaki Shimamoto

      Pages 39-48

   6. Clinical Usefulness of Low-Dose Captopril on Mild to Moderate Essential Hypertension

      • Keishi Abe

      Pages 49-53

   7. Therapeutic Regime of Enalapril Maleate in Japan

      • Takao Saruta

      Pages 55-61

   8. Beneficial and Adverse Effects of Angiotensin Converting Enzyme Inhibitors

      • Kikuo Arakawa

      Pages 63-71

5. Tissue Kallikrein and Its Functional Roles — Kidney and Other Organs —

   1. Structural Analysis of a Rat Renal Kallikrein Gene

      • Lee Chao, Ying-Peng Chen, Cheryl Woodley-Miller, Lingyuan Li, Kay von Harten, Julie Chao

      Pages 73-80

   2. Development of Competitive Antagonists of Bradykinin

      • John M. Stewart, Raymond J. Vavrek

      Pages 81-86

   3. Physiological Role of Renal Kallikrein-Kinin System in Human

      • Kazuaki Shimamoto, Osamu Iimura

      Pages 87-96

   4. Effects of Kinin on Electrolytes Transport and Regulation of Kininase Activity in Distal Nephron Segments of the Rat

      • Kimio Tomita, Kazutomo Ujiie, Yoshitaka Maeda, Yasuhiko Iino, Naoki Yoshiyama, Tatsuo Shiigai

      Pages 97-104

   5. Diversity of Kinin Effects on Transporting Epithelia

      • A. W. Cuthbert, L. J. MacVinish

      Pages 105-111

6. Patho-Physiology of Kallikrein-Kinin System — Inflammation, Allergy and Others —

   1. The Role of T-Kininogen and H and L Kininogens in Health and Disease

      • L. M. Greenbaum, C. Cho, A. Barlas

      Pages 113-116

   2. Recent Studies on the Rule of Kinins in Inflammatory Diseases of Human Airways

      • David Proud, J. Owen Hendley, Jack M. Gwaltney, Robert M. Naclerio

      Pages 117-123

   3. The Kallikrein-Kinin System in Inflammation

      • Allen P. Kaplan, Michael Silverberg, Berhane Ghebrehiwet, Paul Atkins, Burton Zweiman

      Pages 125-136

   4. A Significant Role of Plasma Kallikrein-Kinin System in Plasma Exudation of Rat Carrageenin-Induced Pleurisy

      • Makoto Katori, Masataka Majima, Yoshiteru Harada, Akinori Ueno

      Pages 137-144

The physiological and pathological significance of the kallikrein-kinin system was recently explored extensively, resulting in a rapid accumulation of information regarding their potential importance. This publication provides an integrated picture of the latest information on the kallikrein­ kinin system. It contains contributions from morphologists, geneticists, biochemists, pharmacologists, physiologists, and clinicians. The Fifth International Kinin Congress (Nov. 29-Dec. 3, 1987) provided a forum for the exchange of information and ideas on the kallikrein-kinin system. The participation of more than 350 scientists from 23 countries reflects the widespread interest and international scope of research activity in the physiological and pathological functions of the kallikrein-kinin system. A total of 275 papers including posters were presented, attesting to the unquestioned success of this Congress. These proceedings, in two volumes, contain the collective studies presented, studies of high scientific standard that provoked stimulating and fruitful discussions. Also included in these volumes are the two plenary lectures presented by Dr. H.A. Margolius (USA) and Dr. S. Nakanishi (Japan). During the last decade our knowledge of the role of the kallikrein­ kinin system in health and disease has been greatly advanced by the develop­ ment of antagonists to bradykinin and the introduction to clinical practice of converting enzyme inhibitors. Symposia on converting enzyme and on recent advances in research on the kallikrein-kinin system are included in the proceedings.

• Insulin
• Prostaglandin
• antibody
• antigen
• asthma
• biochemistry
• chromatography
• infectious disease
• inflammation
• kidney
• kinetics
• metabolism
• pharmacology
• physiology
• research

• Tohoku University School of Medicine, Sendai, Miyagi, Japan

  Keishi Abe

• Science University of Tokyo, Tokyo, Japan

  Hiroshi Moriya

• The Osaka Foundation for Promotion of Fundamental Medical Research, Otsu, Shiga, Japan

  Setsuro Fujii

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