Diagnostic and Therapeutic Advances in Pediatric Oncology

1. Front Matter

   Pages i-xi

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2. Understanding the Causes of Tumors of Childhood

   1. Front Matter

      Pages 1-1

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   2. Embryonic development and pediatric oncogenesis

      • David O. Walterhouse, Joon Won Yoon

      Pages 3-38

   3. Immunodeficiency states and related malignancies

      • Kenneth L. McClain

      Pages 39-61

   4. Familial cancer syndromes and genetic counseling

      • Gail E. Tomlinson

      Pages 63-97

3. Embryonal Tumors

   1. Front Matter

      Pages 99-99

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   2. Molecular basis of Wilms’ tumor

      • Paul Grundy

      Pages 101-123

   3. Neuroblastoma: solving a biologic puzzle

      • Susan L. Cohn, Dafna Meitar, Morris Kletzel

      Pages 125-162

   4. Pediatric germ cell tumors

      • Elizabeth J. Perlman, Cynthia Kretschmar

      Pages 163-200

   5. Hepatic malignancies in childhood and adolescence (hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma)

      • Edwin C. Douglass

      Pages 201-212

4. Sarcomas

   1. Front Matter

      Pages 213-213

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   2. Osteosarcoma

      • Jeffrey S. Dome, Cindy L. Schwartz

      Pages 215-251

   3. The Ewing’s sarcoma family of tumors: Ewing’s sarcoma and peripheral primitive neuroectodermal tumor of bone and soft tissue

      • Linda Granowetter, Daniel C. West

      Pages 253-308

   4. Rhabdomyosarcoma: biology and therapy

      • Alberto S. Pappo, David N. Shapiro

      Pages 309-339

5. Late Effects of Childhood Cancer

   1. Front Matter

      Pages 341-341

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   2. Late effects of cancer therapy

      • Elaine R. Morgan, Maureen Haugen

      Pages 343-375

6. Back Matter

   Pages 377-387

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The purpose of Diagnostic and Therapeutic Advances in Pediatric Oncology for the Cancer Treatment and Research Series is to provide an up-to-date summary of how recent advances in cancer research are being applied to the care of children with solid tumors. The interface of cancer research with clinical practice in pediatric oncology has never been more intimate than today. While researchers are identifying oncogenes and tumor suppressor genes and are studying their specific functions, clinicians are using knowledge of oncogenes and tumor suppressor genes for diagnosing cancer in children, for therapeutic decision-making purposes, and for prognostic purposes. The first three chapters in this book describe models for understanding the causes of childhood cancer that were perhaps initially identified by clinicians and that are now being studied and understood by researchers. These chapters will describe research evidence that supports roles for the involvement of normal developmental regulatory genes in childhood oncogenesis, of abnormal immune regulation in childhood oncogenesis, and of heredity in childhood oncogenesis. The next eight chapters are devoted to descriptions of the appli­ cation of new research developments to clinical practice with reference to the most common forms of solid tumors of childhood outside the central nervous system. The final chapter will describe late effects of childhood cancer and its therapy and the impact research is having on understanding and perhaps preventing these late effects.

• cancer treatment
• cell
• childhood
• heredity
• tumor

• Robert H. Lurie Cancer Center, Northwestern University Medical School, Chicago, USA

  David O. Walterhouse, Susan L. Cohn

• Department of Pediatrics, Children’s Memorial Hospital, Chicago, USA

  David O. Walterhouse, Susan L. Cohn

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