Editors:
- Most up-to-date volume that explores evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation
- Highlights early successes as well as failures to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering
- Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion
Part of the book series: Current Cancer Research (CUCR)
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Table of contents (15 chapters)
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Front Matter
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Immune Activation, Suppression and Manipulation of the Immune Antitumor Response
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Front Matter
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Evolving Clinical Immunotherapeutic Strategies
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Front Matter
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Back Matter
About this book
Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets.
Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion.
In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.
Editors and Affiliations
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Sylvester Comprehensive Cancer Center (SCCC), University of Miami School of Medicine, Miami, USA
Joseph D. Rosenblatt
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University of Miami Dept. Microbiology & Immunology, Miami, USA
Eckhard R. Podack
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University of Miami Sylvester Comprehensive Cancer Center, Miami, USA
Glen N. Barber
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Dept. Pediatrics, Louisiana State University Health Sciences Center, New Orleans, USA
Augusto Ochoa
Bibliographic Information
Book Title: Advances in Tumor Immunology and Immunotherapy
Editors: Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa
Series Title: Current Cancer Research
DOI: https://doi.org/10.1007/978-1-4614-8809-5
Publisher: Springer New York, NY
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4614-8808-8Published: 25 October 2013
Softcover ISBN: 978-1-4939-5097-3Published: 23 August 2016
eBook ISBN: 978-1-4614-8809-5Published: 25 October 2013
Series ISSN: 2199-2584
Series E-ISSN: 2199-2592
Edition Number: 1
Number of Pages: IX, 371
Number of Illustrations: 6 b/w illustrations, 29 illustrations in colour
Topics: Cancer Research, Pharmacology/Toxicology