Advances in Chronic Lymphocytic Leukemia

1. Front Matter

   Pages i-xi

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2. B Cell Receptor and Antigens in CLL

   • Andreas Agathangelidis, Stavroula Ntoufa, Kostas Stamatopoulos

   Pages 1-24

3. The CLL Cell Microenvironment

   • Jan A. Burger

   Pages 25-45

4. Acquired Genomic Copy Number Aberrations in CLL

   • Peter Ouillette, Sami Malek

   Pages 47-86

5. Recurrent Gene Mutations in CLL

   • Alejandra Martínez-Trillos, Víctor Quesada, Neus Villamor, Xose S. Puente, Carlos López-Otín, Elías Campo

   Pages 87-107

6. TP53 Aberrations in Chronic Lymphocytic Leukemia

   • Martin Trbusek, Jitka Malcikova

   Pages 109-131

7. Gene Expression and Epigenetic Deregulation

   • Rita Shaknovich

   Pages 133-150

8. Apoptosis Deregulation in CLL

   • Chris Fegan, Chris Pepper

   Pages 151-171

9. Richter Syndrome

   • Davide Rossi, Gianluca Gaidano

   Pages 173-191

10. Molecular Biomarkers in Chronic Lymphocytic Leukemia

    • Sami Malek

    Pages 193-214

11. Critical Signal Transduction Pathways in CLL

    • Asish K. Ghosh, Neil E. Kay

    Pages 215-239

12. Immunotherapies in CLL

    • Jae H. Park, Renier J. Brentjens

    Pages 241-257

13. Towards Targeted Therapy of Chronic Lymphocytic Leukemia

    • Carsten U. Niemann, Jade Jones, Adrian Wiestner

    Pages 259-291

14. Inherited Susceptibility to CLL

    • Helen E. Speedy, Georgina Sava, Richard S. Houlston

    Pages 293-308

15. miR Deregulation in CLL

    • Veronica Balatti, Yuri Pekarky, Lara Rizzotto, Carlo M. Croce

    Pages 309-325

16. Back Matter

    Pages 327-334

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Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course.  While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL.  In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings.  This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply.  Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings.

We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia. 

• CLL
• Cancer research
• Chronic lymphocytic leukemia
• genotoxic

• Department of Internal Medicine, University of Michigan, Ann Arbor, USA

  Sami Malek

Sami N. Malek is an Associate Professor at the Department of Internal Medicine at the University of Michigan Health System. Dr. Malek's research interests include basic and translational questions in Leukemia and Lymphoma. Well known in the field of CLL, Dr. Malek is well-published in the area and is invited to international conferences and seminars to give talks on the topic.

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