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Pathobiology of Cancer Regimen-Related Toxicities

  • Book
  • © 2013

Overview

Editors:
  1. Stephen T. Sonis

    1. Brigham and Women’s Hospital, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Dorothy M. Keefe

    1. Royal Adelaide Hospital, Adelaide, Australia

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    You can also search for this editor in PubMed   Google Scholar

  • Defines the scope, impact and behavior of cancer regimen-related toxicities

  • Discusses the most current thinking around the pathobiology of specific, common, and representative toxicities

  • Discusses the common biological relationships between toxicities, bioinformatical approaches to analysing key and common pathways, and strategies for the development of effective interventions

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-x
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  2. General Concepts Affecting Regimen-Related Toxicities

    1. Front Matter

      Pages 1-1
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  3. General concepts affecting regimen-related toxicities

    1. Epidemiology and Outcomes of Regimen-Related Toxicities

      • Linda S. Elting, Yu-Chia Chang, Pratibha Parelkar
      Pages 3-17

    2. The Biological Basis for Differences in Normal Tissue Response to Radiation Therapy and Strategies to Establish Predictive Assays for Individual Complication Risk

      • Christian Nicolaj Andreassen
      Pages 19-33

    3. The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Significance

      • Edouard I. Azzam, Sonia M. de Toledo, Andrew L. Harris, Vladimir Ivanov, Hongning Zhou, Sally A. Amundson et al.
      Pages 35-61

    4. The Role of Genes on the Metabolism of Chemotherapeutic Agents and Their Impact on Toxicity

      • Young S. Yi, Gil Alterovitz
      Pages 63-73

    5. Animal Models of Regimen-Related Toxicities

      • Gregory Lyng, Richard Logan, Maria Mancini
      Pages 75-95

  4. The Pathobiology of Specific Toxicities

    1. Front Matter

      Pages 97-97
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    2. Nausea and Vomiting

      • Pernille H. Hansen, Jesper Palshof, Jørn Herrstedt
      Pages 99-119

    3. Mucositis

      • Noor Al-Dasooqi, Dorothy M. Keefe, Dorothy M. Keefe, Stephen T. Sonis
      Pages 121-146

    4. Dermatitis and Alopecia

      • Yevgeniy Balagula, Mario E. Lacouture
      Pages 147-166

    5. Fibrosis

      • Lynne A. Murray, Matthew A. Sleeman
      Pages 167-186

    6. Myelosuppression

      • David C. Dale
      Pages 187-205

    7. Neuropathy

      • Elizabeth K. Joseph
      Pages 207-215

    8. Mechanisms of Cancer Related Fatigue

      • Jonathan A. Zombeck
      Pages 217-232

    9. Xerostomia

      • Ana P. Cotrim, Changyu Zheng, Bruce J. Baum
      Pages 233-248

    10. Osteonecrosis

      • Caterina Musolino, Alessandro Allegra
      Pages 249-282

  5. Conclusions and Therapeutic Opportunities

    1. Front Matter

      Pages 283-283
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  6. Conclusions and therapeutic opportunities

    1. Conclusion

      • Stephen T. Sonis, Stephen T. Sonis, Stephen T. Sonis, Dorothy M. Keefe, Dorothy M. Keefe, Dorothy M. Keefe et al.
      Pages 285-286

  7. Back Matter

    Pages 287-292
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Keywords

About this book

The contents of this book will be organized into three sections. The first section defines the scope, impact and behaviour of cancer regimen-related toxicities and frames the issue of balancing treatment success and physiological cost. In the second segment of the book, the most current thinking around the pathobiology of specific, common, and representative toxicities is presented by leading researchers and translational scientists. The final portion of the book discusses the common biological relationships between toxicities, bioinformatical approaches to analysing key and common pathways, and strategies for the development of effective interventions.

Editors and Affiliations

  • Brigham and Women’s Hospital, Boston, USA

    Stephen T. Sonis

  • Royal Adelaide Hospital, Adelaide, Australia

    Dorothy M. Keefe

Bibliographic Information

  • Book Title: Pathobiology of Cancer Regimen-Related Toxicities

  • Editors: Stephen T. Sonis, Dorothy M. Keefe

  • DOI: https://doi.org/10.1007/978-1-4614-5438-0

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-5437-3Published: 27 January 2013

  • Softcover ISBN: 978-1-4899-9070-9Published: 25 June 2015

  • eBook ISBN: 978-1-4614-5438-0Published: 28 January 2013

  • Edition Number: 1

  • Number of Pages: X, 292

  • Topics: Cancer Research, Pharmacology/Toxicology

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