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  • Book
  • © 2013

Prions and Diseases

Volume 2, Animals, Humans and the Environment

  • Authored by a team of leading researchers and clinicians

  • Updated knowledge and concepts on pathogenic prion proteins and prion diseases

  • Present state-of the art findings and hypotheses beyond prions and prion diseases

  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-ix
  2. Bovine Spongiform Encephalopathy

    • Gianluigi Zanusso, Salvatore Monaco
    Pages 1-13
  3. Classical and Atypical Scrapie in Sheep and Goats

    • Christine Fast, Martin H. Groschup
    Pages 15-44
  4. Human Sporadic Prion Diseases

    • Pierluigi Gambetti, Silvio Notari
    Pages 59-72
  5. Prions in the Environment

    • Shannon L. Bartelt-Hunt, Jason C. Bartz, Samuel E. Saunders
    Pages 89-101
  6. The Spectrum of Tau Pathology in Human Prion Disease

    • Gabor G. Kovacs, Herbert Budka
    Pages 103-119
  7. Risk of Transmission of Creutzfeldt–Jakob Disease by Blood Transfusion

    • Alexander H. Peden, Mark W. Head, James W. Ironside
    Pages 121-138
  8. Species Barriers in Prion Disease

    • Suzette A. Priola
    Pages 139-154
  9. Transgenic Mice Modelling

    • Abigail B. Diack, Rona Wilson, Enrico Cancellotti, Barry Bradford, Matthew Bishop, Jean C. Manson
    Pages 155-169
  10. Alternative Models of Prion Diseases

    • Pedro Fernandez-Funez, Edward Málaga-Trillo, Diego E. Rincon-Limas
    Pages 183-199
  11. Diagnosis of Prion Disease: Conventional Approaches

    • Inga Zerr, Joanna Gawinecka, Katharina Stoeck, Maren Breithaupt
    Pages 201-222
  12. Quaking-Induced Conversion Assays for the Detection and Diagnosis of Prion Diseases

    • Jason M. Wilham, Christina D. Orrù, Sarah Vascellari, Andrew G. Hughson, Byron Caughey
    Pages 223-232
  13. The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context

    • T. Dean Airey, Neil R. Cashman
    Pages 233-255
  14. Immunomodulation

    • Thomas Wisniewski, Fernando Goñi
    Pages 269-287
  15. Back Matter

    Pages 289-295

About this book

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

Editors and Affiliations

  • , Department of Pathology, Case Western Reserve University School o, Cleveland, USA

    Wen-Quan Zou

  • , Department of Neuropathology, Case Western Reserve University School o, Cleveland, USA

    Pierluigi Gambetti

Bibliographic Information

Buy it now

Buying options

eBook USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access