Overview
- Editors:
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Nikhil C. Munshi
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Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
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Kenneth C. Anderson
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Dana-Farber Cancer Institute, Dept. Medical Oncology, Harvard Medical School, Boston, USA
Focuses on biology of MM especially, oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies
Explores all clinically important targets including those which have either therapeutic or prognostic significance
Provides perspective on new developments and information with emphasis both on basic science as well as its clinical impact
Includes supplementary material: sn.pub/extras
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Table of contents (11 chapters)
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Myeloma Immune and Antibody Targets
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- Ross Brown, P. Joy Ho, John Gibson, Douglas Joshua
Pages 3-24
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- Surinder S. Sahota, Natalia Savelyeva, Debora Joseph-Pietras, Niklas Zojer, Jason Rice
Pages 73-110
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- Roberto Bellucci, Edwin P. Alyea
Pages 111-129
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- Jooeun Bae, R. H. Prabhala, Nikhil C. Munshi
Pages 131-154
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New Agents
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Front Matter
Pages 155-155
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- Abhishek Singla, Shaji Kumar
Pages 181-213
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- Anuj Mahindra, Jacob Laubach, Constantine Mitsiades, Paul Richardson
Pages 215-228
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- Alessandra Larocca, Antonio Palumbo
Pages 229-255
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Back Matter
Pages 277-287
About this book
Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Editors and Affiliations
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Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA
Nikhil C. Munshi
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Dana-Farber Cancer Institute, Dept. Medical Oncology, Harvard Medical School, Boston, USA
Kenneth C. Anderson
