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Ten Years of Progress in GW/P Body Research

  • Book
  • © 2013

Overview

Editors:
  1. Edward K. L. Chan

    1. College of Dentistry, Department of Oral Biology, University of Florida, Gainesville, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Marvin J. Fritzler

    1. Dept. Medicine & Medical Biochemistry, University of Calgary, Calgary, Canada

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    You can also search for this editor in PubMed   Google Scholar

  • Provides a history of the discovery of cytoplasmic structures
  • Serves as a 10 year review of researchers' current knowledge in subcellular structures
  • This book appeals to cell biologists, investigators involved in microRNA and post-translational regulation of gene expression research, clinical scientiss, and industries that are now using knowledge of the miRNA pathway to design and develop new therapeutics for a broad range of conditions
  • Includes supplementary material: sn.pub/extras

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi
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  2. Introduction: The GW Body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology

    • Edward K. L. Chan, Marvin J. Fritzler
    Pages 1-4

  3. The Discovery of GW Bodies

    • Marvin J. Fritzler, Edward K. L. Chan
    Pages 5-21

  4. The Discovery and Analysis of P Bodies

    • Saumya Jain, Roy Parker
    Pages 23-43

  5. Autoantibodies to Argonaute 2 (Su Antigen)

    • Minoru Satoh, Jason Y. F. Chan, Angela Ceribelli, Monica Vazquez del-Mercado, Edward K. L. Chan
    Pages 45-59

  6. GW/P-Bodies and Autoimmune Disease

    • Donald B. Bloch, Rita A. Nobre, Wei-Hong Yang
    Pages 61-70

  7. Function of GW182 and GW Bodies in siRNA and miRNA Pathways

    • Bing Yao, Songqing Li, Edward K. L. Chan
    Pages 71-96

  8. Post-transcriptional Stimulation of Gene Expression by MicroRNAs

    • Sooncheol Lee, Shobha Vasudevan
    Pages 97-126

  9. Gawky (GW) is the Drosophila melanogaster GW182 Homologue

    • Jing Li, Tom C. Hobman, Andrew J. Simmonds
    Pages 127-145

  10. The Role of GW182 Proteins in miRNA-Mediated Gene Silencing

    • Joerg E. Braun, Eric Huntzinger, Elisa Izaurralde
    Pages 147-163

  11. Quantifying Argonaute Proteins In and Out of GW/P-Bodies: Implications in microRNA Activities

    • Anthony K. L. Leung, Phillip A. Sharp
    Pages 165-182

  12. Deadenylation and P-Bodies

    • Chyi-Ying A. Chen, Ann-Bin Shyu
    Pages 183-195

  13. Relationship of GW/P-Bodies with Stress Granules

    • Georg Stoecklin, Nancy Kedersha
    Pages 197-211

  14. Relationship of Other Cytoplasmic Ribonucleoprotein Bodies (cRNPB) to GW/P Bodies

    • Joanna J. Moser, Marvin J. Fritzler
    Pages 213-242

  15. An SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182

    • Joanna J. Moser, Edward K. L. Chan, Marvin J. Fritzler
    Pages 243-259

  16. Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research

    • Edward K. L. Chan, Bing Yao, Marvin J. Fritzler
    Pages 261-270

  17. Back Matter

    Pages 271-276
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About this book

GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan’s group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.

Editors and Affiliations

  • College of Dentistry, Department of Oral Biology, University of Florida, Gainesville, USA

    Edward K. L. Chan

  • Dept. Medicine & Medical Biochemistry, University of Calgary, Calgary, Canada

    Marvin J. Fritzler

Bibliographic Information

  • Book Title: Ten Years of Progress in GW/P Body Research

  • Editors: Edward K. L. Chan, Marvin J. Fritzler

  • DOI: https://doi.org/10.1007/978-1-4614-5107-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2013

  • Hardcover ISBN: 978-1-4614-5106-8Published: 07 December 2012

  • Softcover ISBN: 978-1-4939-0251-4Published: 29 January 2015

  • eBook ISBN: 978-1-4614-5107-5Published: 09 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 276

  • Topics: Human Genetics, Cell Biology, Biochemistry, general

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