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Systems Biology of Apoptosis

  • Book
  • © 2013

Overview

Editors:
  1. Inna N. Lavrik

    1. Otto von Guericke University, Department of Translational Inflammation, Institute of Experimental Internal Medic, Magdeburg, Germany

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  • First book to merge Systems Biology and Apoptosis research

  • Dr. Inna Lavrik is one of the leading researchers in this emerging area

  • She has published many papers on Systems Biology applications to Apoptosis

  • Includes supplementary material: sn.pub/extras

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xii
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  2. Modeling Formalisms in Systems Biology of Apoptosis

    • Stefan Kallenberger, Stefan Legewie
    Pages 1-32

  3. Systems Biology of Death Receptor-Induced Apoptosis

    • Kolja Schleich, Inna N. Lavrik
    Pages 33-56

  4. Systematic Complexity Reduction of Signaling Models and Application to a CD95 Signaling Model for Apoptosis

    • Dennis Rickert, Nicolai Fricker, Inna N. Lavrik, Fabian J. Theis
    Pages 57-84

  5. Systems Biology of the Mitochondrial Apoptosis Pathway

    • Jochen H. M. Prehn, Heinrich J. Huber, Carla O’Connor
    Pages 85-99

  6. Systems Biology of Cell Death in Hepatocytes

    • Rebekka Schlatter, Kathrin Schmich, Christoph Borner, Michael Ederer, Irmgard Merfort
    Pages 101-123

  7. Understanding Different Types of Cell Death Using Systems Biology

    • Laurence Calzone, Andrei Zinovyev, Boris Zhivotovsky
    Pages 125-143

  8. Modeling Single Cells in Systems Biology

    • Nicolai Fricker, Inna N. Lavrik
    Pages 145-161

  9. Cytokine–Cytokine Cross Talk and Cell-Death Decisions

    • Christopher D. Deppmann, Kevin A. Janes
    Pages 163-180

  10. Genetic and Genomic Dissection of Apoptosis Signaling

    • Christina Falschlehner, Michael Boutros
    Pages 181-197

  11. Back Matter

    Pages 199-203
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Keywords

About this book

Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.

Editors and Affiliations

  • Otto von Guericke University, Department of Translational Inflammation, Institute of Experimental Internal Medic, Magdeburg, Germany

    Inna N. Lavrik

Bibliographic Information

  • Book Title: Systems Biology of Apoptosis

  • Editors: Inna N. Lavrik

  • DOI: https://doi.org/10.1007/978-1-4614-4009-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-4008-6Published: 10 September 2012

  • Softcover ISBN: 978-1-4899-9312-0Published: 15 October 2014

  • eBook ISBN: 978-1-4614-4009-3Published: 13 September 2012

  • Edition Number: 1

  • Number of Pages: XII, 204

  • Topics: Systems Biology, Apoptosis, Biomedicine general

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