Prevention of Type 2 Diabetes

1. Front Matter

   Pages i-xiii

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2. Prevention of Type 2 Diabetes; from Science to Therapies

   • Emily Jane Gallagher, Derek LeRoith

   Pages 1-9

3. Pathophysiology: Loss of β-Cell Function

   • Ele Ferrannini, Andrea Mari

   Pages 11-29

4. Pathophysiology of Insulin Resistance: Implications for Prevention

   • Shamsa Ali, Vivian A. Fonseca

   Pages 31-39

5. Epidemiology Including Youth Through Adulthood and Socioeconomic Impact

   • Helen Looker

   Pages 41-59

6. Prediabetes Genes in Pima and Amish

   • Leslie J. Baier

   Pages 61-80

7. Predicting Diabetes

   • Rachel Dankner, Jesse Roth

   Pages 81-102

8. Screening for Prediabetes and Diabetes

   • Amir Tirosh

   Pages 103-115

9. Neuropathy in Prediabetes and the Metabolic Syndrome

   • Aaron I. Vinik, Marie-Laure Nevoret

   Pages 117-142

10. Interventional Trials to Prevent Diabetes: Diabetes Prevention Program

    • Vanita R. Aroda, Robert E. Ratner

    Pages 143-166

11. Decreasing Postprandial Plasma Glucose Using an α-Glucosidase Inhibitor in Subjects with IGT for the Prevention of Type 2 Diabetes Mellitus: The STOP-NIDDM Trial

    • Jean-Louis Chiasson, Markku Laakso, Markolf Hanefeld

    Pages 167-187

12. Da Qing, Finnish DPP, Tripod, and Dream: Lifestyle and Thiazolidinediones in the Prevention of Diabetes

    • Mariela Glandt, Zachary Bloomgarden

    Pages 189-202

13. Community Approaches to Diabetes Prevention

    • Ann Albright, David Williamson

    Pages 203-219

14. Think Locally, Act Locally, Extend Globally: Diabetes Prevention Through Partnerships with Local Communities

    • Carol R. Horowitz, Brett Ives

    Pages 221-237

15. Global Challenge in Diabetes Prevention from Practice to Public Health

    • Peter E. H. Schwarz

    Pages 239-250

16. Back Matter

    Pages 251-259

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There is a world-wide epidemic on obesity. This epidemic is driving the immense proportions of Type 2 diabetes across the globe. While there are numerous therapies for treating Type 2 diabetes, the most effective therapy is prevention. Prevention of Type 2 diabetes can be achieved properly by simultaneous prevention of obesity. Prediabetes, or metabolic syndrome, is the period between simple obesity and diabetes, and this critical period needs to be identified in a more consistent and systematic manner by clinicians worldwide. Clinical trials have indicated that diabetes prevention can be achieved by lifestyle changes and also by certain medications, though none are yet approved for use in prevention. On the other hand, there are funding agencies such as the NIH, CDC, and State Institutions that are interested in studying the prevention paradigms in different communities and ethnic minorities who are most prone to this epidemic. For these reasons, this title by renowned physician-scientist Derek LeRoith is both timely and vitally important for academic physicians, practitioners, allied health care providers, analysts, community activists, and all others interested in this increasing epidemic. This book provides a unique and comprehensive synthesis of the prevention and early diagnosis of Type 2 Diabetes, focusing on identifying risk factors and then moving into topics that address how to prevent their progression to full-blown diabetes. The difficult task of changing patients’ behavior is given special emphasis. The chapters in this practical volume are written by a wide range of international experts, reflecting the editor’s distinguished, internationally renowned career. The volume is organized in eight sections: an introduction to the overall issue of prevention, definitions of values based on ADA guidelines, pathophysiology, discussion of a range of interventional trials regarding prevention, and an overview of state-of-the-art clinical managementapproaches. Comprehensive and timely, Prevention of Type 2 Diabetes: From Science to Therapy is an essential reference for those treating and researching Type 2 Diabetes.

• Diabetes
• Glucose Thresholds
• Metabolic Syndrome
• Prevention
• Type 2 Diabetes

• , Department of Medicine, Mount Sinai School of Medicine, New York, USA

  Derek LeRoith

Derek LeRoith, MD, PhD, is the editor of 6 Springer titles: five on the biomedicine side and one from clinical medicine.

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