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Sphingolipids and Metabolic Disease

  • Book
  • © 2011

Overview

Editors:
  1. L. Ashley Cowart

    1. Department of Biochemistry and Molecular Biology, Medical University of South Carolina, and Ralph H. Johnson Veteran’s Administration, Charleston, USA

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  • Addresses the fundamentals of sphingolipid metabolism and analysis, as well as the roles of sphingolipids in these disease processes
  • Features findings that sphingolipids may regulate cholesterol homeostasis through SREBP and lipid efflux
  • Presents broad overviews of tissue-specific effects of sphingolipids, while emphasizing interrelatedness of cellular processes and cross-talk between organs

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 721)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Sphingolipid Metabolism and Analysis in Metabolic Disease

    • Sarah E. Brice, L. Ashley Cowart
    Pages 1-17

  3. Sphingolipids and Cardiovascular Diseases: Lipoprotein Metabolism, Atherosclerosis and Cardiomyopathy

    • Xian-Cheng Jiang, Ira J. Goldberg, Tae-Sik Park
    Pages 19-39

  4. Heart Sphingolipids in Health and Disease

    • Marcin Baranowski, Jan Górski
    Pages 41-56

  5. Blood Sphingolipids in Homeostasis and Pathobiology

    • Samar M. Hammad
    Pages 57-66

  6. Adipose Tissue and Ceramide Biosynthesis in the Pathogenesis of Obesity

    • Fahumiya Samad, Leylla Badeanlou, Charmi Shah, Guang Yang
    Pages 67-86

  7. Sphingolipids and Hepatic Steatosis

    • Benjamin T. Bikman, Scott A. Summers
    Pages 87-97

  8. Glycosphingolipids and Insulin Resistance

    • Johannes M. Aerts, Rolf G. Boot, Marco van Eijk, Johanna Groener, Nora Bijl, Elisa Lombardo et al.
    Pages 99-119

  9. Glycosphingolipids and Kidney Disease

    • Andrew R. Mather, Leah J. Siskind
    Pages 121-138

  10. Sphingolipid Synthetic Pathways are Major Regulators of Lipid Homeostasis

    • Tilla S. Worgall
    Pages 139-148

  11. Back Matter

    Pages 149-152
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Keywords

About this book

Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.

Editors and Affiliations

  • Department of Biochemistry and Molecular Biology, Medical University of South Carolina, and Ralph H. Johnson Veteran’s Administration, Charleston, USA

    L. Ashley Cowart

About the editor

L. Ashley Cowart obtained her BS in Biology in 1995 from Furman University in Greenville, South Carolina, and her PhD in Biochemistry in 2001 from Vanderbilt University in Nashville, Tennesee. After postdoctoral work in the laboratory of Dr. Yusuf Hannun, she joined the faculty at the Medical University of South Carolina in Charleston, South Carolina, where she currently holds the position of Assistant Professor of Biochemistry and Molecular Biology. Dr. Cowart’s main research focus is the regulation of sphingolipid metabolism in diabetes and obesity and the roles of sphingolipids in pathological outcomes associated with these disorders. In addition to research, she is involved with graduate admissions and education.

Bibliographic Information

  • Book Title: Sphingolipids and Metabolic Disease

  • Editors: L. Ashley Cowart

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-0650-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2011

  • Hardcover ISBN: 978-1-4614-0649-5Published: 05 August 2011

  • eBook ISBN: 978-1-4614-0650-1Published: 15 September 2011

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVIII, 148

  • Number of Illustrations: 26 b/w illustrations

  • Topics: Molecular Medicine, Metabolic Diseases

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