Overview
- Provides a comprehensive overview of the scientific and regulatory challenges
- Gives description of the types of systems, major areas of current application and research together with current commercial applications
- The reader is introduced to the host response to biomaterials/foreign body and the influence of environmental conditions on the design and development of long acting injections and implants
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Delivery Science and Technology (ADST)
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Table of contents (24 chapters)
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Front Matter
Keywords
About this book
Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability.  An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient.  This book surveys and summarizes the field.Â
Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants.
This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
Editors and Affiliations
About the editors
Dr. Jeremy Wright is a Principal Engineer at the DURECT Corporation in Cupertino, California. He has over 30 years of experience in the development of drug delivery systems. He has been a key contributor to the development of implantable osmotic systems for veterinary and human use (DUROS®) and is currently involved in research and development of injectable depot systems. Dr. Wright is the inventor on over 50 patents.
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Dr. Diane J. Burgess is Distinguished Professor of Pharmaceutics, at the University of Connecticut. Her research efforts focus on gene and drug delivery and she has over 140 refereed publications. Dr. Burgess was the 2010 President of the Controlled Release Society (CRS), the 2002 President of the American Association of Pharmaceutical Scientists (AAPS) and is a CRS, AAPS and an American Institute for Medical and Biological Engineering (AIMBE) fellow. She is editor of the International Journal of Pharmaceutics.
Bibliographic Information
Book Title: Long Acting Injections and Implants
Editors: Jeremy C. Wright, Diane J. Burgess
Series Title: Advances in Delivery Science and Technology
DOI: https://doi.org/10.1007/978-1-4614-0554-2
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Controlled Release Society 2012
Hardcover ISBN: 978-1-4614-0553-5Published: 14 December 2011
Softcover ISBN: 978-1-4899-8913-0Published: 03 March 2014
eBook ISBN: 978-1-4614-0554-2Published: 29 January 2012
Series ISSN: 2192-6204
Series E-ISSN: 2192-6212
Edition Number: 1
Number of Pages: XVI, 560
Topics: Biomedicine general, Pharmaceutical Sciences/Technology
