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Epilepsy

Animal and Human Correlations

  • Book
  • © 2012

Overview

  • This volume examines features of animal and human studies related to both simple and complex partial seizures.
  • Typical as well as atypical seizures are described whenever possible, studies in primates receive careful attention.
  • Rather than offering an inclusive survey of every published study relating to epilepsy in animals and humans, the book offers judiciously selected material with clear correlative relevance.
  • Includes supplementary material: sn.pub/extras

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Table of contents (40 chapters)

  1. Introduction

  2. INTRODUCTION

  3. Generalized Seizures

  4. GENERALIZED SEIZURES

  5. Partial Epilepsies

  6. PARTIAL EPILEPSIES

Keywords

About this book

The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7‐9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.

Reviews

“This is a comprehensive text and atlas on animal and human studies of Epilepsy. … I highly recommend this book to the following audiences: students, fellows, researchers, neurologists, neurosurgeons, and undergraduates.” (Joseph J. Grenier, Amazon.com, September, 2015)

“For the clinical neurologists and epileptologists dedicated to the care of children and adults affected with epilepsy, a concise book like Epilepsy … is a good attempt to become a source for those seeking rapid immersion in the essentials of translational epilepsy research that have tried to explain those critical aspects of epileptogenesis that involve acquired and developmental seizures. … it is a good foundation for those looking for a quick initial reference, which may not be available in rapidly accessible vast internet sources.” (Luis E. Bello-Espinosa, The Canadian Journal of Neurological Sciences, Vol. 40 (1), January, 2013)

Authors and Affiliations

  • , Department of Cell Biology and Anatomy, The Chicago Medical School, Rosalind Fra, Chicago, USA

    David W. McCandless

About the author

About the Author:
The work of Dr. David W. McCandless spanned over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He was the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless served on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Most recently, he served as the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.

Bibliographic Information

  • Book Title: Epilepsy

  • Book Subtitle: Animal and Human Correlations

  • Authors: David W. McCandless

  • DOI: https://doi.org/10.1007/978-1-4614-0361-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-4614-0108-7

  • Softcover ISBN: 978-1-4899-9747-0

  • eBook ISBN: 978-1-4614-0361-6

  • Edition Number: 1

  • Number of Pages: XV, 532

  • Topics: Neurosciences, Neurology, Neurochemistry

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