Molecular and Cellular Mechanisms of Neuronal Plasticity

1. Front Matter

   Pages i-viii

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2. Molecular Specificity of Synaptic Changes Responsible for Associative Memory

   • Daniel L. Alkon

   Pages 1-15

3. Behavioral and Mechanistic Bases of Long-Term Habituation in the Crab Chasmagnathus

   • Daniel Tomsic, Arturo Romano, Héctor Maldonado

   Pages 17-35

4. Bioactive Lipids and Gene Expression in Neuronal Plasticity

   • Nicolas G. Bazan

   Pages 37-49

5. Surface Protein Phosphorylation by Ecto-Protein Kinases

   • Yigal H. Ehrlich, Michael V. Hogan, Zofia Pawlowska, Andrzej Wieraszko, Ethel Katz, Tomasz Sobocki et al.

   Pages 51-71

6. Extracellular ATP-Induced Apoptosis in PC12 Cells

   • Albert Y. Sun, Yong-Mei Chen

   Pages 73-83

7. The Role of The Neural Growth Associated Protein B-50/Gap-43 in Morphogenesis

   • L. H. J. Aarts, P. Schotman, J. Verhaagen, L. H. Schrama, W. H. Gispen

   Pages 85-106

8. Avian Hippocampus as a Model to Study Spatial Orientation-Related Synaptic Plasticity

   • Andrzej Wieraszko

   Pages 107-129

9. Metabotropic Glutamate Receptors in the Plasticity of Excitatory Responses in the Hippocampus

   • Lisa R. Merlin

   Pages 131-144

10. Familial Amyotrophic Lateral Sclerosis and Alzheimer’s Disease

    • Philip C. Wong, David R. Borchelt, Michael K. Lee, Carlos A. Pardo, Gopal Thinakaran, Lee J. Martin et al.

    Pages 145-159

11. Proteins Implicated In Alzheimer Disease

    • Kira S. Ermekova, Alex Chang, Nicola Zambrano, Paola de Candia, Tommaso Russo, Marius Sudol

    Pages 161-180

12. Influence of Phospholipids and Sequential Kinase Activities on Tau in Vitro

    • Thomas B. Shea, Fatma J. Ekinci

    Pages 181-201

13. Cell Culture Models of Neuronal Degeneration and Neuroprotection

    • Efthimia T. Kokotos Leonardi, Catherine Mytilineou

    Pages 203-222

14. Aging and Dementia of the Alzheimer type in Persons with Mental Retardation

    • Henryk M. Wisniewski, Wayne Silverman

    Pages 223-225

15. Back Matter

    Pages 227-229

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Numerous studies have proven the biological basis of memory formation and have begun to identify the biochemical traces and cellular circuits that are formed by experience, and which participate int the storage of information in the brain, its retention for long durations, and its retrieval upon demand. Cells in the nervous system have the capability of undergoing extremely long-lasting alterations in response to hormonal, pharmacological, and environmental stimulations. The mechanisms underlying this neuronal plasticity are activated by experiential inputs and operate in the process of learning and the formation of memories in the brain. This volume presents research areas which have not been highlighted in the past. In addition to studies on the involement of functional proteins in neuronal adaptation, this volume presents recent developments on the critical roles of bioactive lipids and nucleotides in these processes. In addition to the widely studied role of second messengers, a review of studies on extracellular phosphorylation systems operating on the surface of brain neurons is presented.The first section of the volume presents studies of basic mechanisms operating in a wide range of adaptive processes. The second section presents recent advances in investigations that have demonstrated the clinical implications of this research. These include: state of the art use of transgenic models in studies of molecular and cellular mechanisms implicated in familial Alzheimer's disease and Amyotrophic Lateral Sclerosis; studies of specific proteins implicated in Alzheimer's disease, including an adapter that binds to the beta-amyloid precurser protein (beta-APP) and the microtubular protein Tau and its membrane-bound counterpart. The advantages of using cell culture models for elucidating the causes of neuronal degeneration and for identifying mechanisms of neuroprotection are also presented among the chapters in the section on clinical implications.

• Alzheimer
• Nervous System
• Parkinson
• gene expression
• genes
• neurons

• The College of Staten Island of The City University of New York, USA

  Yigal H. Ehrlich

• The CSI/IBR Center for Developmental Neuroscience Staten Island, New York, USA

  Yigal H. Ehrlich

• The City University Graduate School, New York, USA

  Yigal H. Ehrlich

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