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Hepatic Encephalopathy, Hyperammonemia, and Ammonia Toxicity

  • Book
  • © 1994

Overview

Editors:
  1. Vicente Felipo

    1. Instituto de Investigaciones Citologicas de la F. I. B., Valencia, Spain

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    You can also search for this editor in PubMed   Google Scholar

  2. Santiago Grisolia

    1. Instituto de Investigaciones Citologicas de la F. I. B., Valencia, Spain

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 368)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-viii
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  2. Animal Models of Hepatic Encephalopathy and Hyperammonemia

    • Kevin D. Mullen, Sigurbjorn Birgisson, Reynaldo C. Gacad, Hari Conjeevaram
    Pages 1-10

  3. Brain Metabolism in Encephalopathy Caused by Hyperammonemia

    • Richard A. Hawkins, Anke M. Mans
    Pages 11-21

  4. In Vivo Brain Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) in Hepatic Encephalopathy

    • R. A. F. M. Chamuleau, B. A. P. M. Vogels, D. K. Bosman, W. M. M. J. Bovée
    Pages 23-31

  5. Role of the Cellular Hydration State for Cellular Function: Physiological and Pathophysiological Aspects

    • Dieter Häussinger, Wolfgang Gerok
    Pages 33-44

  6. Astrocyte-Neuron Interactions in Hyperammonemia and Hepatic Encephalopathy

    • Jan Albrecht, Lidia Faff
    Pages 45-54

  7. Spinal Seizures in Ammonia Intoxication

    • W. Raabe
    Pages 55-64

  8. Molecular Mechanism of Acute Ammonia Toxicity and of its Prevention by L-Carnitine

    • Vicente Felipo, Elena Kosenko, María-Dolores Miñana, Goizane Marcaida, Santiago Grisolía
    Pages 65-77

  9. Portal-Systemic Encephalopathy: a Disorder of Multiple Neurotransmitter Systems

    • Roger F. Butterworth
    Pages 79-88

  10. The GABA Hypothesis — State of the Art

    • E. Anthony Jones, Cihan Yurdaydin, Anthony S. Basile
    Pages 89-101

  11. Neuropharmacologic Modulation of Hepatic Encephalopathy: Experimental and Clinical Data

    • Peter Ferenci, Andreas Herneth, Andreas Püspök, Petra Steindl
    Pages 103-112

  12. S-Adenosyl-L-Methionine Synthetase and Methionine Metabolism Deficiencies in Cirrhosis

    • José M. Mato, Luis Alvarez, Pablo Ortiz, Jesús Mingorance, Cristina Durán, María A. Pajares
    Pages 113-117

  13. Diagnosis and Therapy of Hepatic Encephalopathy

    • Antoni Mas, Joan Manuel Salmerón, Joan Rodés
    Pages 119-123

  14. Neomycin Reduces the Intestinal Production of Ammonia from Glutamine

    • Richard A. Hawkins, John Jessy, Anke M. Mans, Antonio Chedid, Mary R. DeJoseph
    Pages 125-134

  15. N-Acetylglutamate Synthetase (NAGS) Deficiency

    • J. P. Colombo
    Pages 135-143

  16. Ornithine Transcarbamylase Deficiency: A Model for Gene Therapy

    • Manal A. Morsy, C. Thomas Caskey
    Pages 145-154

  17. Retroviral Gene Transfer for LDL Receptor Deficiency into Primary Hepatocytes

    • Jean-Christophe Pages, Marion Andreoletti, Myriam Bennoun, Dominique Franco, Pascale Briand, Anne Weber
    Pages 155-159

  18. The “Carnitine System”: Recent Aspects

    • Noris Siliprandi, R. Venerando, V. Tassani
    Pages 161-164

  19. Use of Hepatocyte Cultures for Liver Support Bioreactors

    • Jörg C. Gerlach
    Pages 165-171

  20. Hepatitis C Viral Infection after Orthotopic Liver Transplantation

    • Joaquín Berenguer, Martín Prieto, José Mir, Juan Cordoba, Miguel Rayón
    Pages 173-179
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Keywords

About this book

This volume contains the papers presented at the International Symposium on "Cirrhosis, Hyperammonemia and Hepatic Encephalopathy", held in Valencia, Spain, January 24th-27th, 1994. Liver cirrhosis and other hepatic dysfunctions such as fulminant hepatic failure and congenital defects of urea cycle enzymes can lead to hepatic encephalopathy, coma and death. Hepatic encephalopathy is one of the main causes of death in western countries. The ability to detoxify ammonia by its incorporation into urea is diminished by impaired liver function, resulting in increased ammonia levels in blood and brain. Hyperammonemia is considered one of the main factors in the mediation of hepatic encephalopathy and the classical clinical treatments are directed towards reducing blood ammonia levels. However, the molecular bases of the pathogenesis of hepatic encephalopathy and the role of hyperammonemia in this process remain unclear and several hypotheses have been proposed. To clarify the mechanisms involved in hepatic encephalopathy and hyperammonemia suitable animal models are necessary. The animal models available and the ideal features of an animal model are presented in the initial part of the book.

Editors and Affiliations

  • Instituto de Investigaciones Citologicas de la F. I. B., Valencia, Spain

    Vicente Felipo, Santiago Grisolia

Bibliographic Information

  • Book Title: Hepatic Encephalopathy, Hyperammonemia, and Ammonia Toxicity

  • Editors: Vicente Felipo, Santiago Grisolia

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-1989-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1994

  • Hardcover ISBN: 978-0-306-44985-7Published: 31 January 1995

  • Softcover ISBN: 978-1-4613-5820-6Published: 21 October 2012

  • eBook ISBN: 978-1-4615-1989-8Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 219

  • Topics: Gastroenterology, Hepatology, Animal Anatomy / Morphology / Histology, Plant Sciences, Neurosciences

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