Skip to main content
SpringerLink
Log in
Book cover

Chemistry and Biology of Pteridines and Folates

Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17–22, 2001

  • Conference proceedings
  • © 2002

Overview

Editors:
  1. Sheldon Milstien
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Gregory Kapatos
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Robert A. Levine
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  4. Barry Shane
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (110 papers)

  1. Front Matter

    Pages i-xxiii
    Download chapter PDF

  2. Gowland Hopkins Lecture

    1. Making Methionine: A Love Affair with Folate

      • Rowena G. Matthews
      Pages 1-8

  3. Novel Chemistry of Pteridines

    1. Structure Elucidations of Dimeric Pteridines

      • Wolfgang Pfleiderer
      Pages 9-17

    2. A Selective Procedure for 6-Subsituted Pterin Derivatives: Synthesis and Substitution of Pterin 6-Triflate

      • Shizuaki Murata, Masato Kujime, Kazunari Kudoh
      Pages 19-23

    3. Solution and Solid Phase Synthesis of Pteridines, Purines and Related Compounds

      • S. La Rosa, P. H. Boyle, C. L. Gibson, D. Guiney, C. J. Suckling
      Pages 25-29

    4. Synthesis of Pteridines With C-2 And C-6 Functional Group Diversity

      • D. Guiney, P. H. Boyle, C. L. Gibson, S. La Rosa, C. J. Suckling
      Pages 31-35

    5. Stereospecific Synthesis of 2-Desamino-Tetrahydropterins as Probes of Hydroxylase Cofactor Recognition

      • Sundar Vasudevan, Steven W. Bailey, Shirley B. Dillard, June E. Ayling
      Pages 37-41

    6. New Pyranopterin Chemistry Related to Molybdenum and Tungsten Enzymes

      • D. Guschin, W. Belliston, I. M. Müller, B. Fischer
      Pages 43-47

    7. Application of FDCD Spectroscopy for Determination of Chiralities of Biologically Important Pteridines

      • Ning Chen, Kazuhisa Ikemoto, Takashi Sugimoto, Shizuaki Murata, Hiroshi Ichinose, Toshiharu Nagatsu
      Pages 49-53

    8. Photo-Oxidation of Sepiapterin Produces Pterin-6-Carboxylic Acid and H2O2 in Vitro

      • H Rokos, K U Schallreuter
      Pages 55-59

  4. Pteridine-Dependent Enzymes: Structure, Function and Regulation

    1. Regulation of Tyrosine Hydroxylase by S-Glutatiolation: Relevance to Conditions Associated with Dopamine Neuronal Damage

      • Donald M. Kuhn
      Pages 61-65

    2. The Conformation of Tetrahydro-Biopterin Free and Bound to Aromatic Amino Acid Hydroxylases and NOS

      • Knut Teigen, Khanh K. Dao, Nils Åge Frøystein, Antonius C. F. Gorren, Bernd Mayer, Jeffrey McKinney et al.
      Pages 67-72

    3. Regulatory Properties of the Tetrahydropterin Cofactor in the Reaction Catalysed by Human Tyrosine Hydroxylase Isoforms 1–4

      • B. Almås, D. Clement, T. Flatmark
      Pages 73-77

    4. Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes

      • Bostjan Kobe, Ian G. Jennings, Richard G. H. Cotton
      Pages 79-84

    5. Interaction of Phosphorylated Tyrosine Hydroxylase with 14-3-3 Proteins: Effects on Phosphorylation Kinetics

      • R. Kleppe, K. Toska, J. Haavik
      Pages 85-89

    6. Mechanistic Studies of Tryptophan Hydroxylase

      • Paul F. Fitzpatrick, S. Colette Daubner, Graham R. Moran
      Pages 91-95

    7. Role of PHE313/TRP326 in Determining Substrate Specificity in Tryptophan and Phenylalanine Hydroxylases

      • Jeffrey McKinney, Knut Teigen, Nils Åge Frøystein, Per M. Knappskog, Jan Haavik, Aurora Martínez
      Pages 97-102

    8. Possible Contributions of Labile Asparagine Residues to Differences in Regulatory Properties of Human and Rat Phenylalanine Hydroxylase

      • R. M. N. Carvalho, T. Solstad, N. E. Robinson, A. B. Robinson, T. Flatmark
      Pages 103-107

    9. 3-(2-Thienyl)-L-Alanine as a Competitive Substrate Analogue and Activator of Human Phenylalanine Hydroxylase

      • A. J. Stokka, T. Flatmark
      Pages 109-113

    10. The N-Terminus of Human Tyrosine Hydroxylase is Responsible for its Association with Phospholipid Bilayers

      • Matthías Thórólfsson, Arturo Muga, Aurora Martinez
      Pages 115-119
Back to top

Keywords

About this book

Pteridine and folate research has long been recognized as important for many biological processes, such as amino acid metabolism, nucleic acid synthesis, neurotransmitter synthesis, cancer, cardiovascular function, and growth and development of essentially all living organisms. Defects in synthesis, metabolism and/or nutritional availability of these compounds have been implicated as major causes of common disease processes, e.g. cancer, inflammatory disorders, cardiovascular disorders, neurological diseases, autoimmune processes, and birth defects.
Since pteridine and folate biology uses concepts and experimental techniques drawn from all of these disciplines, the breadth of this volume is its great strength, bringing together researchers from a wide variety of fields including biochemistry, chemistry, physics, biophysics, genetics, microbiology, cell and molecular biology, virology, immunology, cancer, neurobiology and medicine. This volume should be a valuable and unique reference work for scientists with interests in these areas as well as those seeking up to date information.

Bibliographic Information

  • Book Title: Chemistry and Biology of Pteridines and Folates

  • Book Subtitle: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health, Bethesda, Maryland, June 17–22, 2001

  • Editors: Sheldon Milstien, Gregory Kapatos, Robert A. Levine, Barry Shane

  • DOI: https://doi.org/10.1007/978-1-4615-0945-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-7923-7675-0Published: 31 May 2002

  • Softcover ISBN: 978-1-4613-5317-1Published: 05 November 2012

  • eBook ISBN: 978-1-4615-0945-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXIII, 677

  • Topics: Biochemistry, general, Human Genetics, Neurosciences, Cancer Research

Publish with us

Policies and ethics

Back to top

Search

Navigation