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Molecular and Cellular Biology of Neuroprotection in the CNS

  • Book
  • © 2002

Overview

Editors:
  1. Christian Alzheimer

    1. Institute of Physiology, University of Kiel, Kiel, Germany

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 513)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Neuronal Cell Death Overview of Basic Mechanisms

    1. Front Matter

      Pages 1-1
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    2. Excitatory Amino Acid Neurotoxicity

      • Thomas Gillessen, Samantha L. Budd, Stuart A. Lipton
      Pages 3-40

    3. Neuronal Survival and Cell Death Signaling Pathways

      • Richard S. Morrison, Yoshito Kinoshita, Mark D. Johnson, Saadi Ghatan, Joseph T. Ho, Gwenn Garden
      Pages 41-86

    4. Detrimental and Beneficial Effects of Injury-Induced Inflammation and Cytokine Expression in the Nervous System

      • Stoll Guido, Jander Sebastian, Michael Schroeter
      Pages 87-113

    5. Cellular and Molecular Determinants of Glial Scar Formation

      • Ann Logan, Martin Berry
      Pages 115-158

  3. Ion Channels, Receptors and Signaling Pathways

    1. Front Matter

      Pages 159-159
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    2. Na+Channels and Ca2+ Channels of the Cell Membrane as Targets of Neuroprotective Substances

      • Christian Alzheimer
      Pages 161-181

    3. Intracellular Ca2+ Handling

      • Rod J. Sayer
      Pages 183-196

    4. Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands

      • Peter J. Flor, Giuseppe Battaglia, Ferdinando Nicoletti, Fabrizio Gasparini, Valeria Bruno
      Pages 197-223

    5. A Role for Glutamate Transporters in Neurodegenerative Diseases

      • Davide Trotti
      Pages 225-248

    6. Purines and Neuroprotection

      • Trevor W. Stone
      Pages 249-280

    7. Heat Shock Proteins and Neuroprotection

      • Midori A. Yenari
      Pages 281-299

  4. Neurotrophic Factors as Neuroprotective Agents

    1. Front Matter

      Pages 301-301
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    2. Neurotrophins

      • Georg Dechant, Harald Neumann
      Pages 303-334

    3. Fibroblast Growth Factors and Neuroprotection

      • Christian Alzheimer, Sabine Werner
      Pages 335-351

    4. TGF-ßS and Their Roles in the Regulation of Neuron Survival

      • Klaus Unsicker, Kerstin Krieglstein
      Pages 353-374

    5. Vascular Endothelial Growth Factor

      • Hugo H. Marti
      Pages 375-394
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Keywords

About this book

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.

Editors and Affiliations

  • Institute of Physiology, University of Kiel, Kiel, Germany

    Christian Alzheimer

Bibliographic Information

  • Book Title: Molecular and Cellular Biology of Neuroprotection in the CNS

  • Editors: Christian Alzheimer

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-0123-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2002

  • Hardcover ISBN: 978-0-306-47414-9Published: 31 January 2003

  • Softcover ISBN: 978-1-4613-4934-1Published: 05 November 2012

  • eBook ISBN: 978-1-4615-0123-7Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVII, 501

  • Topics: Neurosciences, Pharmacology/Toxicology

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